优降宁对四氢巴马汀排空大鼠脑内儿茶酚胺作用的影响

dl-四氢巴马汀(dl-Tetrahydropalmatine,THP)是中药延胡索(Corydalis ambigua)的有效成分之一,有镇静、安定和镇痛作用。本文作者曾报道,THP有利血平样作用,能排空动物脑内多巴胺(DA)、去甲肾上腺素(NA)和5-羟色胺及心脏内的NA,提出THP为一短效单胺排空剂。众所周知,利血平类化合物的作用可为单胺氧化酶抑制剂(MAOI)所翻转。如在利血平以前给予MAOI,则前者的镇静作用翻转为兴奋,对单胺的排空作用亦被

THE INFLUENCE OF PARGYLINE ON DEPLETION OF CATECHOLAMINES IN RAT BRAIN BY DL-TETRAHYDROPALMATINE

DL-Tetrahydropalmatine (THP) is an active principle found in the Chinese herb Corydalis ambigua. It possesses sedative and analgesic activities. THP had been reported to deplete dopamine (DA), noradrenaline (NA) and serotonin in rat brain. The effect of reserpine in reducing the transmitters and its sedative action could be reversed by MAOI i. e. reserpine-reversal. In order to investigate the influence of pargyline on THP induced depletion of catecholamines, NA, DA and their metabolites were measured by high performance liquid chromatography coupled with electrochemical detection. It was shown that the decrease of NA and DA concentrations in the limbic area was reversed by pretreatment with pargyline, whereas that in the striatal area returned to normal. From this study further evidence was obtained to support the hypothesis that THP is a monoamine depletor with reserpine-like action.