| 21─氨基类固醇U─75412E对石英细胞毒性抑制作用的研究 |
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| 引用本文： | 黄曙海.21─氨基类固醇U─75412E对石英细胞毒性抑制作用的研究[J].应用预防医学,1995(4). |
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| 作者姓名： | 黄曙海 |
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| 作者单位： | 广西职业病防治研究所 |
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| 摘 要： | 观察了２１一氨基类固醇类药物Ｕ一７５４１２Ｅ对石英致肺巨噬细胞损伤的抑制作用。结果表明，Ｕ一７５４１２Ｅ具有很强的清除活性氧基团稳定细胞膜作用，显著降低了过氧化氢，乳酸脱氢酶和超氧化物歧化酶的释放。阻断了石英对肺泡巨噬细胞的损伤。
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| 关 键 词： | 21一氨基类固醇，石英，活性氧基团 |
Ptotective Effects of 21-Aminosteroids U-75412E Against Quartz-induced Cytotoxici-ties |
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| Huang Shu-hai,et al..Ptotective Effects of 21-Aminosteroids U-75412E Against Quartz-induced Cytotoxici-ties[J].Journal of Applied Preventive Medicine,1995(4). |
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| Authors: | Huang Shu-hai |
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| Institution: | Guangxi Instituteof Occupational Disease Nanning 530021 |
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| Abstract: | In the present study,we investigatedthe effectiveness of U-75412E,a kind of 21-aminosteroids,in amelioration of quartz-induced cy-totoxicities.Results showed that U-75412E signifi-cantly reduced the releases of hydrogen peroxide,lac-tate dehydrogenase,and superoxide dismutase,fromquartz-stimulated pulmonary alveolar macrophages.In addition,U-75412E scavenged hydroxyl radicalsgenerated by quartz from hydrogen peroxide.Thesein vitro studies indicate that administration of 21-aminosteroius in quartz-induced lung injury mayprotect lung against oxidant injury. |
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| Keywords: | aminosteroids quartz reac-tive oxygen spoies |
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