Food anthocyanins decrease concentrations of TNF-α in older adults with mild cognitive impairment: A randomized,controlled, double blind clinical trial |
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Authors: | Vinicius A do Rosario Zoe Fitzgerald Samantha Broyd Amelia Paterson Steven Roodenrys Susan Thomas Vida Bliokas Jan Potter Karen Walton Katrina Weston–Green Maziar Yousefi David Williams Ian MR Wright Karen Charlton |
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Institution: | 1. School of Medicine, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, 2522, Australia;2. Illawarra Health & Medical Research Institute, Wollongong, NSW, 2522, Australia;3. Department of Rehabilitation & Medical Psychology, Port Kembla Hospital, Warrawong, NSW, 2502, Australia;4. School of Psychology, Faculty of Arts, Social Sciences and Humanities, University of Wollongong, Wollongong, NSW, 2522, Australia;5. Molecular Horizons, University of Wollongong, Wollongong, NSW, 2522, Australia;6. Department of Agriculture and Fisheries, Brisbane, QLD, 4108, Australia;7. College of Medicine and Dentistry, James Cook University, Cairns, QLD, 4870, Australia |
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Abstract: | Background & aimsVascular function, blood pressure and inflammation are involved in the pathogenesis of major chronic diseases, including both cardiovascular disease (CVD) and mild cognitive impairment (MCI). This study investigated the effects of food anthocyanins on microvascular function, 24-h ambulatory blood pressure (ABP) and inflammatory biomarkers in older adults with MCI.Methods and resultsThirty-one participants with MCI 19 female, 12 male, mean age 75.3 (SD 6.9) years and body mass index 26.1 (SD 3.3) kg/m2], participated in a randomized, controlled, double-blind clinical trial (Australian New Zealand Clinical Trials Registry: ACTRN12618001184268). Participants consumed 250 mL fruit juice daily for 8 weeks, allocated into three groups: a) high dose anthocyanins (201 mg); b) low dose anthocyanins (47 mg); c) control. Microvascular function (Laser Speckle Contrast Imaging combined with a post-occlusive reactive hyperaemia test), 24h ABP and serum inflammatory biomarkers were assessed before and after the nutritional intervention.ResultsParticipants in the high anthocyanins group had a reduction in serum tumor necrosis factor alpha (TNF-α) (P = 0.002) compared to controls and the low anthocyanins group (all P's > 0.05). Serum IL-6, IL-1β, c-reactive protein, and parameters of microvascular function and 24h ABP were not altered by any treatment.ConclusionA daily high dose of fruit-based anthocyanins for 8 weeks reduced concentrations of TNF-α in older adults with MCI. Anthocyanins did not alter other inflammatory biomarkers, microvascular function or blood pressure parameters. Further studies with a larger sample size and longer period of follow-up are required to elucidate whether this change in the immune response will alter CVD risk and progression of cognitive decline. |
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Keywords: | Anthocyanins Cardiovascular diseases Inflammation Blood pressure Endothelium Vascular Mild cognitive impairment |
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