内蒙古儿童青少年高三酰甘油腰围表型与高尿酸血症的关系

  目的  研究内蒙古6~17岁儿童青少年高尿酸血症(hyperuricemia, HUA)的患病情况和高三酰甘油腰围(hypotriglyceridemic-waist, HTW) 表型的检出情况，并探讨两者的关系，为内蒙古儿童青少年高尿酸血症的防治提供依据。  方法  采用多阶段分层随机抽样的方法选择内蒙古8个旗县(区)的小学、初中和高中2 175名学生进行问卷调查、体格检查和实验室检测。采用二元Logistic回归分析HTW表型和HUA的相关性。  结果  研究对象HTW表型检出率为2.1%，男生检出率(2.5%)高于女生(1.6%)(χ2=14.50，P < 0.05)。血尿酸(serum uric acid, SUA)平均水平为308.00(259.00，371.00)mmol/L，性别间差异有统计学意义(Z=-9.87，P < 0.05)，HUA患病率为21.1%。HTW表型的HUA患病率(44.4%)高于其他表型，其次为高腰围(enlarged waist, EW)表型(36.2%)。校正其他因素后，EW表型(OR=1.76，95%CI=1.26~2.47)和HTW表型(OR=2.25，95%CI=1.12~4.52)与HUA发病均呈正相关(P值均 < 0.05)。  结论  内蒙古6~17岁儿童青少年的HUA患病率较高，HTW表型与高尿酸血症呈正相关。在高尿酸血症的预防中，应加强对具有HTW表型儿童青少年的关注。

Association between hyperuricemia and hypertriglyceridemic-waist phenotype in children and adolescents in Inner Mongolia

  Objective  To investigate the prevalence and association of hyperuricemia (HUA) and hypertriglyceridemic-Waist (HTW) phenotype in children and adolescents aged 6-17 years in Inner Mongolia, providing a basis for the prevention and treatment of hyperuricemia in adolescents in Inner Mongolia.  Methods  A total of 2 175 students of primary, junior high, and senior high school students from eight counties (districts) in Inner Mongolia were chosen and received a questionnaire survey, physical examination, and laboratory test by used a multi-stage stratified random sampling approach. The association between the HTW phenotype and HUA was analyzed using binary Logistic regression.  Results  The prevalence of the HTW phenotype was 2.1%, with boys(2.5%) higher than that of girls(1.6%) (χ2=14.50, P < 0.05). The average SUA level of the participants was 308.00 (259.00, 371.00) mmol/L, with a statistically significant sex difference(Z=-9.87, P < 0.05). The prevalence of HUA was 21.1%. The frequency of HUA in the HTW phenotype(44.4%) was higher than in other phenotypes, followed by enlarged waist (EW) phenotype. After controlling for associated variables, the EW phenotypes (OR=1.76, 95%CI=1.26-2.47) and HTW phenotypes (OR=2.25, 95%CI=1.12-4.52) were associated with higher risk for HUA(P < 0.05).  Conclusion  In Inner Mongolia, the prevalence of HUA in children and adolescents aged 6-17 years is high, and there shows a positive association between the HTW phenotype and hyperuricemia. For the prevention of hyperuricemia, more attention should be paid to children and adolescents with HTW phenotype.