The association of genetically determined serum glycine with cardiovascular risk in East Asians |
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| Authors: | Xuling Chang Ling Wang Shou Ping Guan Brian K. Kennedy Jianjun Liu Chiea-Chuen Khor Adrian F. Low Mark Yan-Yee Chan Jian-Min Yuan Woon-Puay Koh Yechiel Friedlander Rajkumar Dorajoo Chew-Kiat Heng |
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| Affiliation: | 1. Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore;2. Khoo Teck Puat, National University Children''s Medical Institute, National University Health System, Singapore 119074, Singapore;3. Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672, Singapore;4. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;5. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore;6. Centre for Healthy Longevity, National University of Singapore, National University Health System, Singapore, Singapore;7. Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore, Singapore;8. Buck Institute for Research on Aging, Novato, CA, USA;9. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore;10. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 169856, Singapore;11. National University Heart Centre, National University Health System, Singapore, 119074, Singapore;12. Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA;13. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA;14. Health Systems and Services Research, Duke-NUS Medical School Singapore, Singapore 169857, Singapore;15. Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore;p. School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel |
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| Abstract: | Background and aimsGlycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians.Methods and resultsWe conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138).ConclusionOur study, a first in East Asians, suggest a protective role of glycine against CAD. |
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| Keywords: | Genome-wide association study Circulating glycine concentration Cardiovascular risk Genetic association |
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