不同运动方式对肥胖青少年炎症反应影响的Meta分析

目的 系统评价不同运动方式对肥胖青少年炎症反应改善的差异性,为选择合理运动方式应对青少年全身慢性炎症反应导致肥胖相关的各种慢性疾病提供参考.方法 检索中国知网(CNKI)、PubMed、Web of Science、EBSCOhost等数据库,采用Cochrane评价工具对纳入的肥胖青少年炎症指标影响的随机对照试验(R...

Meta-analysis of effectiveness of different exercises on inflammatory response in obese adolescents

  Objective  To systematically evaluate effectiveness of exercises on inflammatory response among obese adolescents.  Methods  By searching CNKI, PubMed, Web of Science, EBSCOhost and other databases, randomized controlled trials (RCTs) on the influence of different exercises on inflammatory indicators in obese adolescents were collected according to the inclusion and exclusion criteria. Cochrane evaluation tools were conducted methodological studies on the included literature quality evaluation, and RevMan 5.3 analysis software was used for statistical analysis.  Results  A total of 21 RCTs were included, involving 1 020 subjects. The results of Meta-analysis showed that aerobic training (AT) and aerobic plus resistance training (AT+RT) could significantly reduce BMI, serum C-reactive protein (CRP) and leptin levels in obese adolescents. In addition, the effects of AT+RT on pro-inflammatory CRP (MD=-0.52, 95%CI=-0.75--0.30, P < 0.01), leptin (MD=-7.20, 95%CI=-10.45--3.94, P < 0.01) and anti-inflammatory adiponectin (MD=1.28, 95%CI=1.01-1.55, P < 0.01) were stronger than AT. High intensity interval training (HIIT) was associated with BMI reduction (MD=-1.14, 95%CI=-1.92--0.36, P < 0.01) and increased adiponectin in obese adolescents (MD=1.79, 95%CI=1.09-2.50, P < 0.01), and HIIT was superior in improving adiponectin level in obese adolescents than AT and AT+RT.  Conclusion  Long-term and regular AT, AT+RT and HIIT can reduce inflammation in obese adolescents. HIIT is a notable exercise method for obese adolescents to resist inflammation.