儿童青少年孤独症谱系障碍与肥胖关联的累积Meta分析

  目的  对肥胖和孤独症谱系障碍(ASD)流行病学研究进行Meta分析，以探究儿童青少年孤独症谱系障碍和肥胖之间的关联，为改善ASD儿童青少年患者日常生活质量提供一定指导作用。  方法  系统检索PubMed、CNKI(2010年1月—2022年1月)中与肥胖、ASD相关的文献，采用Meta分析报告OR值。并对权重、体质量指数(BMI)获得方式、年龄等分类指标进行亚组分析。  结果  共筛选11篇文献纳入分析，总样本包括336 830名参与者，其中ASD患者58 187名，正常发育者278 643名。经Meta分析，与正常人相比，ASD儿童青少年有更高的肥胖发病风险(OR=1.80，95%CI=1.74~1.86)。根据BMI获得方式分组后，与正常人相比，BMI由客观测量、从病历中获得、父母报告获得的ASD患者有更高的肥胖发病风险，OR值(OR值95%CI)分别为1.43(1.04~1.96)，5.23(4.44~6.16)，2.57(1.79~3.69)。根据年龄分组后，与正常人相比，14~20岁ASD儿童青少年患者有更高的肥胖发病风险，OR值(OR值95%CI)=2.19(1.21~3.94)。  结论  相较于正常发育同龄人，ASD儿童青少年患者发生肥胖的风险更高。应在饮食、体力活动方面正确引导ASD患者，尤其是在青春期，避免其发生肥胖及肥胖引起的其他疾病。

Cumulative Meta-analysis of the association between obesity and autism spectrum disorders in children and adolescents

  Objective  This study conducts a Meta-analysis on the epidemiological studies of obesity and autism spectrum disorder (ASD) in order to explore the relationship between autism spectrum disorder and obesity in children and adolescents, and to provide some guidance for improving the quality of daily life of children and adolescents with ASD.  Methods  PubMed and CNKI (January, 2010-January, 2022) were systematically searched for literature related to autism spectrum disorders reported the or value by Meta-analysis, and compared the weight, BMI acquisition method.  Results  A total of 11 literatures were selected for analysis. The total sample included 336 830 participants, including 58 187 patients with ASD and 278 643 patients with normal development. Through Meta-analysis, children and adolescents with ASD had a higher risk of obesity than normal people (OR=1.80, 95%CI=1.74-1.86). when stratified by BMI acquisition, autistic patients with BMI obtained from objective measurement, medical records and parents' reports had a higher risk of obesity than normal people, and the OR value (95%CI) was 1.43(1.04-1.96), 5.23(4.44-6.16), 2.57(1.79-3.69). When stratified by age, children and adolescents with ASD aged 14 to 20 years had a higher risk of obesity than normal people. The OR value (95%CI) was 2.19(1.21-3.94).  Conclusion  Compared with healthy peers, children and adolescents with ASD have a higher risk of obesity. ASD patients need guidance in diet and physical activity, especially in adolescence, to prevent obesity or diseases caused by obesity.