| MDR1-mRNA在原发性大肠癌中定量测定及临床意义 |
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| 引用本文： | 姜喜远,陈光,马丽娜,王有德. MDR1-mRNA在原发性大肠癌中定量测定及临床意义[J]. 中国实验诊断学, 2000, 4(3): 122-124 |
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| 作者姓名： | 姜喜远 陈光 马丽娜 王有德 |
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| 作者单位： | 1. 白求恩医科大学第一临床学院,普外科,吉林,长春,130021
2. 白求恩医科大学基础医学院,分子生物学教研室 |
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| 摘 要： | 探讨大肠癌ｍｄｒ１基因与肿瘤生物学行为的关系及ｍｄｒｌ基因表达分级标准制定的临床意义。方法采用ＲＴ－ＰＣＲ方法检测了６５例大肠腺癌患者肿瘤组织中ｍｄｒｌ基因表达水平并进行程度分级。结果ｍｄｒｌ基因表达水平与大肠腺癌分化程度相关,但与肿瘤侵袭程度、淋巴结转移程度及远处转移与否无关。
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| 关 键 词： | 大肠癌 多药耐药性 基因表达 MDR1－mRNA |
| 文章编号： | 1007-4287(2000)03-0122-03 |
| 修稿时间： | 2000-03-30 |
Significance of mdr1-mRNA quantitative analysis in primary colorectal carcinoma |
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| JIA NC Xi-yuan, CHEN Cuang, MALi-na,et al.. Significance of mdr1-mRNA quantitative analysis in primary colorectal carcinoma[J]. Chinese Journal of Laboratory Diagnosis, 2000, 4(3): 122-124 |
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| Authors: | JIA NC Xi-yuan CHEN Cuang MALi-na et al. |
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| Abstract: | Objedtive To explore the relationship between multidrug resistance of colorectal carcinoma and its biologic be havior and to evaluate the siedcance of drawing out the degree'e standard of mdrl gene expession. Methods The expression of mdrl gene was measured in 65 colorectal careinoma samples with RT-PCR. Results The level of mdrl gene expression in colorectal careinoma appeared correlating with the degree of histological differentiation, but no with the primary tumours, the regional lymph nodes and the distant metastasis. Conclusion Measuring the expression of mdrl gene in colorectal carcinoma may individualize the chemotherapy protocol for the patient. |
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| Keywords: | Colorectal carcinoma Multidrug resistance mdrl gene expression RT-PCR |
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