临床营养研究中随机对照研究质量评价

目的评价两种主要临床营养期刊中随机对照试验（RCT）的质量。方法查阅2000～2008年《中国临床营养杂志》和《肠外与肠内营养》发表的RCT研究，按Cochrane协作网标准评价，并进行Jadad评分。结果两种期刊共发表238篇RCT研究，Jadad评分为（1．65±0．82）分。高质量RCT仅28篇（11．76％），评分为满分5分的仅5篇（2．10％）。随机分组的方法、组间可比性、纳入排除标准、盲法、撤除和退出的数量和理由、样本含量等方面存在各种问题。结论国内临床营养领域RCT研究的设计和质量控制还存在不足或欠缺，水平尚待提高。

Evaluation of randomized controlled trials in the studies of clinical nutrition

Objective To evaluate the quality of the randomized controlled trials (RCTs) published in two key Chineze journals on clinical nutrition.Methods The articles published in CHINESE JOURNAL OF CLIN-ICAL NUTRlTION and PARENTERAL & ENTERAL NUTRITION from 2000 to 2008 were reviewed and the RCTs were identified according to criteria of the handbook of Cochrane Collaboration.The Jadad scale was used to evalu-ate the quality of these RCTs.Results Totally 238 RCT articles were published in these two journals in this peri-od.The Jadad score of all RCT articles was 1.65±0.82.Twenty-eight articles (11.76%) were of high quality and only 5 articles (2.10%) were identified 5 points.There were some problems in the RCTs design,conduction and analyses included unclear randomization methods,poor comparison,lack of inclusion and exclusion criteria.less blinding employment,unclear withdrawals and dropouts,and improper sample size.Conclusion The design and quality control of Chinese clinical nutrition RCTs still have some problems and require further improvement.