| 咬合创伤对三叉神经脊束核尾侧亚核c-fos的影响 |
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| 引用本文： | 贾静,刘洪臣,国文,邓宏燕,杨德圣,刘雪梅.咬合创伤对三叉神经脊束核尾侧亚核c-fos的影响[J].口腔颌面修复学杂志,2010,11(6). |
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| 作者姓名： | 贾静 刘洪臣 国文 邓宏燕 杨德圣 刘雪梅 |
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| 作者单位： | 武警总医院口腔科 解放军总医院口腔医学研究所 武警疾控中心 解放军总医院口腔医学中心 |
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| 基金项目： | 国家自然科学基金，北京市自然科学基金 |
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| 摘 要： | 目的:观察三叉神经脊束核尾侧亚核(Sp5C)中c-fos(核磷酸蛋白原癌基因)对咬合创伤的反应,探讨神经元在咬合创伤中的功能变化。方法:将直径0.5mm方丝粘固于大鼠左侧上颌第一磨牙,形成左侧磨牙早接触的创伤咬合,观察咬合创伤后1,3,7d,2w,4w,5w时Sp5C中c-fos蛋白的表达变化。结果:正常大鼠Sp5C中偶见极少量c-fos阳性神经元细胞,咬合创伤后7d,c-fos阳性神经元明显增加,2w时达到高峰,4w时开始下降。结论:咬合创伤刺激诱导了Sp5C中神经元的激活。
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| 关 键 词： | 咬合创伤 核磷酸蛋白原癌基因 三叉神经脊束核尾侧亚核 |
The changes of c-fos to occlusal trauma in rat spinal trigeminal subnucleus candalis |
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| JIA Jing,LIU Hong-chen,GUO Wen,DENG Hong-yan,YANG De-sheng,LIU Xue-mei.The changes of c-fos to occlusal trauma in rat spinal trigeminal subnucleus candalis[J].Chinese Journal of Prosthodontics,2010,11(6). |
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| Authors: | JIA Jing LIU Hong-chen GUO Wen DENG Hong-yan YANG De-sheng LIU Xue-mei |
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| Institution: | .(Department of Stomatology; General Hospital of Chinese People s Armed Police Forces; Beijing 100039; China); |
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| Abstract: | Objective: To investigate the changes of c-fos in the Sp5C during occlusal trauma and study the effect of occlusal trauma on neurons.Methods: The occlusal surface of the left first maxillary molar was raised 0.5mm with the square wire.On 1,3,7d,2w,4w and 5w after teeth operation,immunofluorescence histochemical was used to examine the number of c-fos contanining neurons in the Sp5C.Results: The number of c-fos-containing neurons increased significantly in experimental side of Sp5C at 7d after occlusal traum... |
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| Keywords: | occlusal trauma c-fos spinal trigeminal subnucleus candalis |
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