| 姜黄素对小鼠实验性肝损伤的保护作用 |
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| 引用本文： | 刘永刚,陈厚昌,蒋毅萍. 姜黄素对小鼠实验性肝损伤的保护作用[J]. 中国中药杂志, 2003, 28(8): 756-758 |
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| 作者姓名： | 刘永刚 陈厚昌 蒋毅萍 |
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| 作者单位： | 第一军医大学,药理教研室,广州,510515 |
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| 摘 要： | 目的 :探讨姜黄素对肝脏损伤的保护作用。方法 :分别建立四氯化碳、D-半乳糖胺及卡介苗加脂多糖诱导小鼠肝脏损伤模型 ,以测定血清谷丙氨酸转换酶 (ALT)、谷草氨基酸转换酶 (AST)、一氧化氮 (NO)和肝匀浆丙二醛 (MDA)含量为指标观察姜黄素对肝脏损伤的保护作用。结果 :姜黄素与阳性对照药联苯双酯相仿 ,均能明显降低动物模型的血清ALT ,AST ,NO和肝匀浆MDA含量。结论 :姜黄素具有明显的保肝作用。
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| 关 键 词： | 姜黄素 四氯化碳 D半乳糖胺 卡介苗+脂多糖 |
| 文章编号： | 1001-5302(2003)08-0756-03 |
| 收稿时间： | 2002-09-17 |
Protective Effect of Curcumin on Experimental Liver Injury in Mice |
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| LIU Yong gang;CHEN Hou chang;JIANG Yi ping. Protective Effect of Curcumin on Experimental Liver Injury in Mice[J]. China Journal of Chinese Materia Medica, 2003, 28(8): 756-758 |
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| Authors: | LIU Yong gang CHEN Hou chang JIANG Yi ping |
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| Affiliation: | Department of Pharmacology, First Military Medical University, Guangzhou 510515, Guandong, China. |
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| Abstract: | Objective:To Study the protective effect of curcumin on three models of experimental liver injury in mice.Method:The experimental models of live injury were induced by carbon tetrachloride (CCl4), D-galactosamine ( D-Gal N), and Bacillus Calmette Guerin (BCG) Plus lipolysaccharides (LPS), respectively, in mice. The serum ALT, AST, NO and liver MDA were measured to evaluate the protective effect of curcumin on experimental injury in mice. Result:Curcumin (50 mg·kg-1 , 100 mg·kg-1 , 150 mg·kg-1 ), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG+LPS.Conclusion:Curcumin showed protective effect against liver injury induced by CCl4, D-Gal N, BCG plus LPS. |
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| Keywords: | curcumin CCl, D-Gal N BCG+LPS |
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