Activity of telithromycin compared with seven other agents against 1039 Streptococcus pyogenes pediatric isolates from ten centers in central and eastern Europe |
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| Authors: | B. Bozdogan P. C. Appelbaum L. M. Kelly D. B. Hoellman A. Tambic-Andrasevic L. Drukalska W. Hryniewicz H. Hupkova M. R. Jacobs J. Kolman M. Konkoly-Thege J. Miciuleviciene M. Pana L. Setchanova J. Trupl P. Urbaskova |
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| Affiliation: | Department of Pathology, Hershey Medical Center, 500 University Dr., Hershey, PA 17033, USA,;University Hospital of Infectious Diseases, Zagreb, Croatia,;Children's Hospital of Medical Academy of Latvia, Riga, Latvia,;Sera and Vaccine Laboratory, Warsaw, Poland,;St Cyril and Method Hospital, Bratislava, Slovak Republic,;Case Western Reserve University, Cleveland, Ohio,;University of Ljubljana, Ljubljana, Slovenia,;National Center for Epidemiology, Budapest, Hungary,;9Kaunas Medical University Hospital, Kaunas, Lithuania, Institute Cantacuzino, Bucharest, Romania,;Hospital of Infectious Diseases, Medical Academy, Sofia, Bulgaria,;National Cancer Institute, Bratislava, Slovak Republic and;National Antibiotic Reference Laboratory, Prague, Czech Republic;Tel: +1 717 531 5113 Fax: +1 717 531 7953 E-mail: |
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| Abstract: | In total, 1039 pediatric Streptococcus pyogenes isolates from Bulgaria, Croatia, the Czech Republic, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia and Slovenia were studied. All strains were susceptible to penicillin G, levofloxacin, and quinupristin–dalfopristin, 91–100% to telithromycin, and 82–100% to erythromycin, azithromycin, and clarithromycin, and 90–100% to clindamycin. Macrolide resistance occurred mainly in Slovakia (25%), the Czech Republic (17.3%), and Croatia (15.8%). Overall, 9.7% of S. pyogenes isolates were erythromycin resistant due to erm(B) - or erm(A) -encoded methylases (72.3%) or to a mef(A) -encoded efflux pump (25.7%). One strain had alterations of both 23S rRNA (A2058G Escherichia coli numbering) and ribosomal protein L22 (G95D). |
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| Keywords: | Telithromycin Streptococcus pyogenes macrolide resistance |
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