Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment |
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Authors: | Kelleher James P Centorrino Franca Huxley Nancy A Bates John A Drake Jennifer Kidwell Egli Samy Baldessarini Ross J |
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Affiliation: | Department of Psychiatry, St. Vincent's Hospital Westchester, Harrison, NY 10528, USA. jkelleher@svwsjmc.org |
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Abstract: | The preferential dopamine D(3)-agonist pramipexole (4.25±0.38 mg/day) or placebo were added for up to 12 weeks to ongoing antipsychotic treatment for 24 adult patients with DSM-IV schizophrenia or schizoaffective disorder. Pramipexole was generally well-tolerated (82% trial-completion), and yielded greater decreases in PANSS-total scores (drug/placebo=2.1; p=0.04), with similar decreases in PANSS positive and negative scores and 6.7-fold greater reduction of serum prolactin concentrations compared to placebo. There were no differences in ratings of mood, cognition or extrapyramidal symptoms, all of which were low at intake. |
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