| MMP-2、MMP-9及TIMP-2、TIMP-1在非黑色素性皮肤癌中的表达 |
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| 引用本文： | 张红,邬时国,干亚丹.MMP-2、MMP-9及TIMP-2、TIMP-1在非黑色素性皮肤癌中的表达[J].中国现代医生,2013,51(11):103-105,F0003. |
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| 作者姓名： | 张红 邬时国 干亚丹 |
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| 作者单位： | 浙江省余姚市人民医院普外科,浙江余姚,315400 |
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| 摘 要： | 目的 探讨金属基质蛋白酶MMP-2、MMP-9及其抑制因子TIMP-2、TIMP-1在非黑色素性皮肤癌中的表达.方法 取皮肤癌手术切除标本40份,进行免疫组化检测MMP-2、MMP-9及其抑制因子TIMP-2、TIMP-1的表达.结果 MMP-2、MMP-9在非黑色素皮肤癌中的表达的阳性率、染色强度、表达强度均显著高于正常皮肤.TIMP-2、TIMP-1在非黑色素皮肤癌中的表达的阳性率、染色强度、表达强度均显著低于正常皮肤.结论 基质金属蛋白酶（MMP）在非黑色素性皮肤癌中呈高表达,基质金属蛋白酶组织抑制因子呈低表达,两者比例失衡与皮肤癌的浸润和转移有关.
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| 关 键 词： | 皮肤癌 MMP-2 MMP-9 TIMP-2 TIMP-1 |
Expression of MMP-2, MMP-9, TIMP-2 and TIMP-1 in non-melannoma skin carcinoma |
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| Authors: | ZHANG Hong WU Shiguo GAN Yadan |
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| Institution: | Department of General Surgery, Yuyao People＇s Hospital in Zhejiang Province, Yuyao 315400, China |
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| Abstract: | Objective To discuss expression of MMP-2, MMP-9, TlMP-2 and TIMP-1 in non-melannoma skin car- cinoma. Methods Forty cases of non-melannoma skin carcinoma specimen were selected. MMP-2, MMP-9, TIMP-2 and TIMP-1 were detected. Results Positive rates, staining intensity, expression intensity of MMP-2, MMP-9 in non- melannoma skin carcinoma were higher than normal skin tissue, ositive rates , staining intensity, expression intensity of TIMP-2 and TIMP-1 in non-melannoma skin carcinoma were Sower than normal skin tissue. Conclusion MMPs show high expression in non-melannoma skin carcinoma, and TIMPs show low expression.Imbalance of them connect with non-melannoma skin carcinoma infiltration and metastasis. |
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| Keywords: | Skin carcinoma MMP-2 MMP-9 TIMP-2 TIMP-1 |
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