| Effects of insulin receptor tyrosine protein kinase on insulin resistance after scalding in rats |
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| 引用本文： | 毛旭虎,许霖水. Effects of insulin receptor tyrosine protein kinase on insulin resistance after scalding in rats[J]. 中国人民解放军军医大学学报, 1996, 0(4) |
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| 作者姓名： | 毛旭虎 许霖水 |
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| 作者单位： | Department of Biochemistry，Third Military Medical University，Chongqing，630038 |
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| 摘 要： | Ｅｆｆｅｃｔｓｏｆｉｎｓｕｌｉｎｒｅｃｅｐｔｏｒｔｙｒｏｓｉｎｅｐｒｏｔｅｉｎｋｉｎａｓｅｏｎｉｎｓｕｌｉｎｒｅｓｉｓｔａｎｃｅａｆｔｅｒｓｃａｌｄｉｎｇｉｎｒａｔｓ￥（毛旭虎）（许霖水）ＭａｏＸｕｈｕ，ＸｕＬｉｎｓｈｕｉ（ＤｅｐａｒｔｍｅｎｔｏｆＢ...
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Effects of insulin receptor tyrosine protein kinase on insulin resistance after scalding in rats |
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| Mao Xuhu,Xu Linshui. Effects of insulin receptor tyrosine protein kinase on insulin resistance after scalding in rats[J]. Journal of Medical Colleges of PLA(China), 1996, 0(4) |
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| Authors: | Mao Xuhu Xu Linshui |
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| Abstract: | After the rats were inflicted with 30% TBSA full thickness scalding on their back, the changes of insulin receptor tyrosine protein kinase (IRTPK) were studied on the 4th day postscalding with the phosphorylation of exogenous substrates stimulated with hepatic and muscular plasma membrane in order to explore the possible molecular mechanism of insulin resistance after thermal injury. It was found that insulin resistance appeared in the early stage postscalding while the basic value of phosphorylation of exogenous substrates stimulated with hepatic and muscular plasma membrane was increased and the activity of IPTPK to insulin stimulation was greatly suppressed as compared with the control. These facts suggest that the impaired responses of IRTPK to insulin stimulation may affect the down-stream signal transmission of the insulin receptors and then the signal coupling pathwayfor glucose transmembranous transportation and glycogen synthesis mediated by IRTPK is obstructed and insulinresistance develops. |
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| Keywords: | scalding insulin receptor tyrosine protein kinase insulin resistance rats |
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