| 全身麻醉药与术后认知功能障碍及阿尔茨海默病 |
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| 引用本文： | 杨定东,DAI Ze-ping.全身麻醉药与术后认知功能障碍及阿尔茨海默病[J].国际麻醉学与复苏杂志,2008,29(4). |
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| 作者姓名： | 杨定东 DAI Ze-ping |
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| 作者单位： | 安徽省芜湖市第二人民医院麻醉科,241000 |
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| 摘 要： | 术后认知功能障碍(POCD)的病因复杂,在老年患者中较多见,但其机制尚未明确.全麻药在POCD发生中的作用及其机制已有许多研究,结果复杂而多样.另外,有一些动物或离体研究表明全麻药可促发阿尔茨海默病(AD)的发病过程并可能因此促发AD的发病和导致POCD.因此,研究全麻药在POCD和术后AD发病中的作用,特别是探求其中可能存在的共同机制是有意义的.
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| 关 键 词： | 全身麻醉药 术后认知功能障碍 阿尔茨海默病 |
Association between anesthetics and postoperative cognitive dysfunction and Alzheimer's disease |
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| YANG Ding-dong,DAI Ze-ping.Association between anesthetics and postoperative cognitive dysfunction and Alzheimer's disease[J].international journal of anesthesiology and resuscitation,2008,29(4). |
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| Authors: | YANG Ding-dong DAI Ze-ping |
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| Abstract: | Postoperative lognitive dystunction (POCD) may occur in postoperative period. However, the molecular mechanisms underlying POCD is tmknown. Although many studies in association of anesthetics and POCD have been conducted, the results are muhiplicate. Some recent studies in vitro reported that anesthetics may activate neuropathogenesis of Alzheimer's disease (AD) and supposed that anesthetics may cause POCD or AD. |
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| Keywords: | general anesthetic postoperative cognitive dysfunction alzheimer's disease |
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