Improving drug delivery from medical nebulizers: the effects of increased nebulizer flow rates and reservoirs. |
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| Authors: | T E Corcoran J H Dauber N Chigier A T Iacono |
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| Affiliation: | Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. corcorante@msx.upmc.edu |
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| Abstract: | Drug delivery from jet nebulizers can be considered in terms of the dose inhaled and the respirability of that dose. It is proposed that dose respirability and dose per breath can be controlled through specification of the driving gas flowrate, and that the dose inhaled per breath can also be increased through the use of nebulizer reservoirs. When a Hudson Micromist nebulizer was used and assessments of respirability were made utilizing phase Doppler interferometry, it was noted that the portion of the spray mass in droplet sizes of
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