| 二价锰对不同月龄大鼠线粒体膜电位影响的体外研究 |
| |
| 引用本文： | 张淑华 褚金花 宣登峰 吴萍 李国君 耿荣 郭文瑞. 二价锰对不同月龄大鼠线粒体膜电位影响的体外研究[J]. 首都医科大学学报, 2004, 25(4): 424-426 |
| |
| 作者姓名： | 张淑华 褚金花 宣登峰 吴萍 李国君 耿荣 郭文瑞 |
| |
| 作者单位： | 首都医科大学公共卫生与家庭医学学院(张淑华，褚金花，宣登峰，吴萍，李国君)，北京丰台疾病预防控制中心(耿荣)，北京丰台疾病预防控制中心(郭文瑞) |
| |
| 基金项目： | 国家自然科学基金 (3 0 0 0 0 14 0 )，教育部科学技术研究重点项目 (0 0 13 2 )，北京市科技新星计划 (95 5 810 2 80 0 )，教育部“高等学校骨干教师资助计划 5 2”，北京市教委基金资助项目，北京市卫生局基金资助项目 |
| |
| 摘 要： | 研究二价锰离子对不同月龄大鼠线粒体膜电位的影响。将不同月龄 (4个月和 1 8个月 )Wistar大鼠 ,提取脑线粒体后分为 5组 (5 0、1 0 0、2 0 0、40 0 μmol/L和空白对照 )体外染毒 ,用荧光光度法连续观察 3min内样品荧光值的变化。结果显示 ,各染毒组和对照组间差异均有统计学意义 (P <0 .0 5 ) ;不同月龄大鼠各染毒组间差异也有显著性(P <0 .0 5 )。随着大鼠年龄和染毒剂量的增加 ,线粒体膜功能衰退 ,耐受性降低。
|
| 关 键 词： | 锰 线粒体 膜电位 |
| 收稿时间： | 2004-02-16 |
| 修稿时间： | 2004-02-16 |
Effect of Manganese on Mitochondria Membrane Potential of Different-aged Rats in Vitro |
| |
| Zhang Shuhua,Chu Jinhua,Xuan Dengfeng,Wu Ping,Li Guojun College of Public Health and Family Medicine,Capital University of Medical Sciences Geng Rong,Guo Wenrui Beijing Fengtai Center of Disease Control and Prevention. Effect of Manganese on Mitochondria Membrane Potential of Different-aged Rats in Vitro[J]. Journal of Capital Medical University, 2004, 25(4): 424-426 |
| |
| Authors: | Zhang Shuhua Chu Jinhua Xuan Dengfeng Wu Ping Li Guojun College of Public Health Family Medicine Capital University of Medical Sciences Geng Rong Guo Wenrui Beijing Fengtai Center of Disease Control Prevention |
| |
| Affiliation: | 1. College of Public Health and Family Medicine, Capital University of Medical Sciences;2. Beijing Fengtai Center of Disease Control and Prevention |
| |
| Abstract: | The aim was to study the effect of Mn 2+ exposure on membrane function of different month rats brain mitochondrial. Different-aged (4 months and 18 months) Wistar rats's mitochondria were extracted, exposed to MnCl2·4H2O and then divided into five groups(50, 100, 200, 400 μmol/L and the control group). The fluorescence intensity was detected in successive 3 min by fluorophotometric method. Compared with the control group' the exposed groups showed obvious reduction(P<0.05). In addtion, there was significant difference among the drug-receiving groups(P<0.05). Function and resistance of mitochondrial membrane are decreased with the increase of dosage andages. |
| |
| Keywords: | manganese mitochondria membrane potential |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《首都医科大学学报》浏览原始摘要信息 |
|
点击此处可从《首都医科大学学报》下载免费的PDF全文 |
