5-FU联合顺铂腹腔内热灌注治疗癌性腹水

目的探讨5-FU联合顺铂腹腔内热灌注治疗癌性腹水的临床价值。方法67例癌性腹水患者随机分为2组。单纯腹腔内灌注化疗组33例，热灌注化疗组34例。化疗（5-FU1．0＋顺铂120mg），每周1次连续2周。间隔2周。结果单纯腹腔内灌注组与热灌注组，疗效分别为：3个月：CR，21．21％、35．29％（P〉0．5）；PR，36．36％、47．06％（P〉0．5）；CR＋PR，57．58％、82．35％（P〈0．5）。6个月：CR，27．27％、41．18％（P〉0．5）：PR。42．42％、55．88％（P〉0．5）；CR＋PR，63．64％、94．11％（P〈0．01）；6个月生存率（ER）63．64％、85．29％（P〈0．5）。2组部分病例有不同程度局部疼痛，均可耐受，无需特殊处理；单纯腹腔内灌注组出现化学性腹膜炎5例，热灌注组出现3例。结论腹腔内热灌注化疗治疗癌性腹水，疗效确切，方法简便、经济，不良反应小。同时可提高患者的生活质量，延长生存期，值得基层医院推广。

The clinical value of the 5-FU combined the sequence-platinum with thermo poured into abdominal cavity for treatment cancer ascites

Objective Lnquiring to the clinical value of the 5-FU combined sequence - platinum with thermo-poured into abdominal cavity for treatment cancer ascites. Methods 67 cases of patients with cancer ascites whom randomly divided into two teams, 33 cases were treated with normal intraperitoneal chemotherapy , 34 cases were treated with the hyperthermic intraperitoneal chemotherapy;The chemotherapy （ 5-FU1.0 ＋ sequence-platinum 120 mg ） was 1 time per week,continuously 2 weeks. The interval was 2 weeks. Results The two teams treatment effects of the normal and the hyperthermic intraperitoneal chemotherapy groups were respectively ：3 months ： CR 21.21% , 35.29% （ P 〉 0. 5 ） ; PR 36. 36% ,47. 06% 16 （ P 〉 0. 5 ） ; availability rates were 57. 58 % ,82. 35% （P〈0.5）. 6 months ： CR27.27% ,41.18% （P〉0.5）; PR42.42% , 55.88 % （ P 〉 0. 5 ） ; availability rats 63.64 %, 94. 11% （ P 〈 0. 01 ） ; existence rates （ER） of 6 months were 63.64% , 85.29% （P 〈0. 5） . Partly cases of the two teams occured the different level local pain , all could be bear and needed not to special treatment. 5 cases occured chemistry peritonitis in normal intraperitoneal chemotherapy group , 3 cases occured chemistry peritonitis in the hyperthermic intraperitoneal chemotherapy group. Conclusion The efficacy of the hyperthermic intraperitoneal chemotherapy was definite. The method was simple and convenient and economically. The bad reaction is small. At the same time the life quality of patients can be raised and lengthen existence phase. To popularized was worth for basic hospital.