| 血清MMP-2表达在慢性充血性心力衰竭中的意义 |
| |
| 引用本文： | 赖汝标,江权锋,钟飞雁.血清MMP-2表达在慢性充血性心力衰竭中的意义[J].广州医学院学报,2013(3):25-27. |
| |
| 作者姓名： | 赖汝标 江权锋 钟飞雁 |
| |
| 作者单位： | 广东省韶关市翁源县人民医院ICU,广东韶关512600 |
| |
| 摘 要： | 目的：探讨慢性充血性心力衰竭患者血清基质金属蛋白-2（MMP-2）水平变化规律及其临床意义。方法：将120例慢性心力衰竭患者作为观察组，体检健康者80例作为对照组，比较两组MMP-2水平的差异，同时观察慢性心力衰竭不同分级指标升高情况及其与脑钠肽（BNP）水平的相关性。结果：观察组MMP-2水平显著高于对照组（P〈0．05），且随着心功能分级的升高而增加（P〈0．05）。血清MMP-2水平与LVEF、LVEDV、BNP水平呈正相关（P〈0．05）。结论：MMP-2水平与慢性心力衰竭的发生具有明显相关性．有一定的临床意义。
|
| 关 键 词： | 慢性充血性心力衰竭 基质金属蛋白酶-2 脑钠肽 |
Clinical significance of serum matrix metalloproteinase-2 in chronic congestive heart failure |
| |
| LAI Ru-biao,JIANG Quan-feng,ZHONG Fei-yan.Clinical significance of serum matrix metalloproteinase-2 in chronic congestive heart failure[J].Academic Journal of Guangzhou Medical College,2013(3):25-27. |
| |
| Authors: | LAI Ru-biao JIANG Quan-feng ZHONG Fei-yan |
| |
| Institution: | ( Intensive Care Unit, Wengyuan People＇s Hospital, Shaoguan, Guangdong 512600, China) |
| |
| Abstract: | Objective：To investigate the changes in the level of serum matrix metal protein-2 （MMP-2）and its clinical significance in patients with chronic congestive heart failure（CHF）. Methods： We compared the level of MMP-2 in 120 consecutive patients with CHF （observation group）and 80 healthy subjects who underwent health check-up（control group）. This entailed assessment of the increase in MMP-2 in various grading of severity and the correlation with brain natriuretic peptide （BNP）. Results： Serum MMP-2 level in CHF patients was significantly higher than that in control group（ P 〈 0.05 ） and increased as with the advanced grading of disease severity. Conclusion： The correlation between serum MMP-2 and incidence of CHF may be clinically significant. |
| |
| Keywords: | Chronic congestive heart failure matrix metalloproteinase-2 brain natriuretic peptide |
| 本文献已被 维普 等数据库收录！ |
