血清视黄醇结合蛋白4水平与胎儿生长发育的关系

目的：探讨血清视黄醇结合蛋白4（RBP4）水平与胎儿生长发育的关系。方法：选取2011年5月至2013年2月分娩的200例孕妇作为研究对象，其中正常孕妇（NGT）＋AGA组50例、NGT4-LGA组50例、GDM4-AGA组50例、GDM＋LGA组50例。采用酶联免疫吸附试验测定孕妇血清RBP4水平，并记录孕早期体质指数和新生儿出生体质量等指标。结果：（1）GDM＋AGA组、GDM4-LGA组血清RBP4水平（11．99±0．30）、（12．03±0．27）μg／mL]均高于NGT4-AGA组（9．00±0．26）μg／mL]（P〈0．05）；（2）NGT＋LGA组血清RBP4水平（12．01±0．24）μg／mL]高于NGT4-AGA组（P〈0．05）。结论：GDM患者中血清RBP4水平升高，在没有明显糖耐量受损的情况下，RBP4可能参与加速胎儿生长。

Correlation between maternal serum retinol binding protein-4 and fetal growth

Objective：To study the correlation between maternal serum retinol binding protein-4 （RBP4） concentration and fetal growth. Methods ： We recruited 200 pregnant women who gave delivery between May 2011 and February 2013 and allocated to normal pregnant women（NGT） plus appropriate-for-gestational-age （AGA） neonate （ n = 50 ）, NGT plus large-for-gestational-age （LGA） neonate （ n = 50）, gestational diabetes mellitus women （GDM） plus AGA neonate（ n = 50 ）and GDM women plus LGA neonate group （n = 50）, respectively. Enzymelinked immunosorbent assay（ELISA） was employed to assess the concentration of maternal serum RBP4. The body mass index of first trimester and the weight of neonates at birth were recorded. Results： Compared with NGT plus AGA group,the GDM plus AGA and GDM plus LGA group yielded higher median serum concentration of RBP4 （ 11.99 ± 0.30） μg/ml and （ 12.03 ±0.26 ） μg/ml vs. （9.00 ± 0.26 ） μg/ml, both P 〈 0.051. The NGT plus LGA group evidenced an increased serum RBP4 level compared with NGT plus AGA group （ 12.01 ± 0.24） μg/ ml vs. （ 9.00 ± 0.26 ） μg/ml, P 〈 0.05 ]. Conclusion： Patients with GDM are characterized by increased level of serum RBP4. Maternal serum RBP4 concentration may play an important role in fetal growth in the absence of significant carbohydrate intolerance.