| 水杨酸钠对豚鼠内耳血管通透性的影响 |
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| 引用本文： | 朱瑾,刘兆华. 水杨酸钠对豚鼠内耳血管通透性的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2002, 16(12): 687-688 |
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| 作者姓名： | 朱瑾 刘兆华 |
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| 作者单位： | 1. 第三军医大学附属西南医院耳鼻咽喉科,重庆,400038
2. 第三军医大学附属大坪医院耳鼻咽喉科 |
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| 摘 要： | 目的 :探讨水杨酸钠耳毒性的发生机制。方法 :采用硝酸镧作为示踪剂电镜下观察正常对照组与水杨酸钠组内耳基底膜螺旋血管、血管纹和内淋巴囊毛细血管的血管通透性。结果 :正常对照组基底膜内、外螺旋血管、血管纹毛细血管不具有通透性 ,正常内淋巴囊毛细血管具有一定通透性。水杨酸钠耳毒性发生时上述血管的通透性均增强。结论 :水杨酸钠可使内耳血管通透性发生改变 ,这可能参与了水杨酸钠耳毒性的发生。
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| 关 键 词： | 水杨酸盐耳毒性 毛细血管通透性 内耳 豚鼠 |
| 文章编号： | 1001-1781(2002)12-0687-02 |
| 修稿时间： | 2002-04-13 |
Effects of salicylate on the capillary permeability of inner ear in guinea pigs |
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| ZHU Jin LIU Zhaohua. Effects of salicylate on the capillary permeability of inner ear in guinea pigs[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2002, 16(12): 687-688 |
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| Authors: | ZHU Jin LIU Zhaohua |
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| Affiliation: | Department of Otorhinolaryngology, Southwest Hospital, Third Military Medical University, Chongqing 400038. |
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| Abstract: | Objective:To further understand the mechanism of salicylate ototoxicity. Method: The capillary permeability of inner ear was compared between the normal group and the salicylate ototoxicity group traced with lanthanum by electron microscopy. Result: The normal inner/outer spiral vessels of basilar membrane, strial blood vessels had no permeability, whereas the capillaries of endolymphatic sac showed a certain permeability. In salicylate ototoxicity group, the permeability of the capillaries mentioned above increased significantly. Conclusion: Salicylate may increase the capillary permeability in inner ear, which may participate in the mechanism of the salicylate ototoxicity. |
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| Keywords: | Salicylate ototoxicity Capillary permeability Inner ear Guinea pig |
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