Active Wnt/beta-catenin signaling is required for embryonic thymic epithelial development and functionality ex vivo |
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| Authors: | Krisztian Kvell Aniko V. Fejes Sonia M. Parnell Judit E. Pongracz |
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| Affiliation: | 1. Department of Pharmacological Biotechnology, University of Pecs, Hungary;2. Department of Anatomy, Division of Immunity and Infection, Institute for Biomedical Research, University of Birmingham, UK |
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| Abstract: | The Wnt/beta-catenin signaling pathway plays an important role in the commitment and development of thymic epithelial precursors. Here we document similarities of thymic epithelial development during embryogenesis in human and mouse. We stained for thymic epithelial surface markers (EpCAM1, Ly51, K8) and ligand/receptor pair (Wnt4, Fz4). Our results confirm the relevance of using murine test systems to model human embryonic thymic epithelial cell development. |
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| Keywords: | Embryonic development FoxN1 ICAT Thymic epithelium Wnt |
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