吡啶单萜烯isocantleyine的结构测定

自玄参科植物阴行草(Siphonostegia chinensis Benth)的地上部分分得一吡啶单萜烯类新生物碱,经物理常数测定和光谱(UV,IR,MS,¹HNMR,2D-NMR,¹³CNMR)分析,确定其结构为5H-pyridine-4-carboxylic acid,6,7-dihydro-6-hydroxy-7-methyl-methyl ester,定名为isocantleyine。此外,尚分得一已知内酯类成分loliolide,也是首次自本植物中得到。

THE STRUCTURE IDENTIFICATION OF PYRIDINEMONO TERPENE ISOCANTLEYINE

Siphonostegia chinensis Benth. as a traditional Chinese medicine "liujinu" has been used for centuries in China, but up to date little has been reported about its chemistry. Now, four compounds have been isolated from the aerial parts of this genus. On the basis of spectroscopic analysis (UV, IR, MS, 1HNMR, 13CNMR and 2D-NMR) and chemical evidences, compound I was shown to be a new pyridinemonoterpene alkaloid which is a stereoisomer of the known compound cantleyine, and named isocantleyine. Its structure was determined as 5H-2-pyridine-4-carboxylic acid, 6,7-dihydro-6-hydroxy-7-methyl-methyl ester. Compound III was identified as the known compound loliolide. The other two (II and IV) are still under investigation. This paper deals mainly with the structure identification of compound I.