| caveolae与肿瘤细胞的多药耐药性 |
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| 引用本文： | 王瑞华,时永全. caveolae与肿瘤细胞的多药耐药性[J]. 肿瘤研究与临床, 2006, 18(7): 498-500 |
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| 作者姓名： | 王瑞华 时永全 |
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| 作者单位： | 1. 730000,兰州军区司令部门诊部
2. 第四军医大学西京医院消化内科 |
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| 摘 要： | caveolae是特化的细胞膜微结构域，它由其特异性的被覆蛋白caveolin及多种脂类分子和膜蛋白组成，在细胞外分子的内化、信号的跨膜转导和胆固醇的转运过程中起着重要的作用。新近的研究表明，caveolae及其某些组成成分在肿瘤多药耐药细胞中表达上调，并有可能参与了肿瘤细胞多药耐药性的形成。对caveolae与肿瘤细胞多药耐药性的研究进展进行了综述。
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| 关 键 词： | 被覆蛋白caveolae 肿瘤细胞 多药耐药性 |
| 文章编号： | 1006-9801（2006）07-0498-03 |
| 收稿时间： | 2005-06-02 |
| 修稿时间： | 2006-03-08 |
Caveolae and multidrug resistance of tumor cells |
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| WANG Rui-hua,SHI Yong-quan. Caveolae and multidrug resistance of tumor cells[J]. Cancer Research and Clinic, 2006, 18(7): 498-500 |
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| Authors: | WANG Rui-hua SHI Yong-quan |
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| Affiliation: | Out-Patient Department Affiliated to Headquarters of Lanchow Military Area, Lanchow 730000, China |
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| Abstract: | Caveolae is a specified micro-domain of plasma membrane, which consists of caveolin and many lipid molecules and membrane proteins. Caveolae plays important roles in internalization of extra-membrane molecules, transmembrane signal transdution and transport of cholesterin. Recent studies indicated that caveolae and its components were up-regulated in multidrug resistant tumor ceils and might participate the development of multidrug resistance of tumor ceils. This paper concentrated on the role of caveolae in tumor multidrug resistance. |
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| Keywords: | Caveolae Multidrug resistance Tumor ceils |
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