| 米力农对顽固性心衰患者心功能及血清TNF-α、IL-6、IL-8水平的影响 |
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| 引用本文： | 陈尉华,周巍,曹勤,潘浩,俞愉,龚好,何双军,朱长清. 米力农对顽固性心衰患者心功能及血清TNF-α、IL-6、IL-8水平的影响[J]. 医学临床研究, 2007, 24(9): 1483-1484,1487 |
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| 作者姓名： | 陈尉华 周巍 曹勤 潘浩 俞愉 龚好 何双军 朱长清 |
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| 作者单位： | 上海交通大学医学院附属仁济医院急诊科,上海,200127;上海交通大学医学院附属仁济医院急诊科,上海,200127;上海交通大学医学院附属仁济医院急诊科,上海,200127;上海交通大学医学院附属仁济医院急诊科,上海,200127;上海交通大学医学院附属仁济医院急诊科,上海,200127;上海交通大学医学院附属仁济医院急诊科,上海,200127;上海交通大学医学院附属仁济医院急诊科,上海,200127;上海交通大学医学院附属仁济医院急诊科,上海,200127 |
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| 摘 要： | [目的]观察米力农对顽固性心衰患者心功能及血清肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、白介素8(IL-8)水平的影响.[方法]30例顽固性心衰患者给与米力农治疗10 d,在治疗前、后分别测定血压、心率、心功能、血清TNF-α、IL-6和IL-8水平,同时与30例健康体检者作对照.[结果]虽然给予米力农治疗后患者的心功能、血清TNF-α、IL-6和IL-8水平与对照组比较仍有显著性差异;但较治疗前有显著改善(P＜0.05).[结论]米力农可以一定程度上地改善顽固性心衰患者的心功能,降低血清TNF-α、IL-6、IL-8水平.
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| 关 键 词： | 心力衰竭 充血性/血液 米力农/药理学 肿瘤坏死因子/血液 白细胞介素6/血液 白细胞介素8/血液 |
| 文章编号： | 1671-7171（2007）09-1483,1487-03 |
| 修稿时间： | 2007-06-16 |
Effect of Milrinone on Heart Function and Serum Level of Tumour Necrosis Factor-alpha ,Interleukin-6 and 8 with Refractory Heart Failure |
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| CHEN Wei-hua , ZHOU Wei , CAO Qin , et al. Effect of Milrinone on Heart Function and Serum Level of Tumour Necrosis Factor-alpha ,Interleukin-6 and 8 with Refractory Heart Failure[J]. Journal of Clinical Research, 2007, 24(9): 1483-1484,1487 |
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| Authors: | CHEN Wei-hua ZHOU Wei CAO Qin et al |
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| Affiliation: | Department of Emergency, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200127,China |
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| Abstract: | [Objective] To observe the effect of milrinone on heart function and level of tumour necrosis factor-alpha,interleukin-6 and 8 with refractory heart failure.[Methods]Milrinone was used to 30 patients with refractory heart failure for 10 days.Blood pressure,heart rate and heart function,serum level of tumour necrosis factor-alpha,interleukin-6 and 8 were estimated before and after treatment,and also in 30 healthy volunteers in control group.[Results]Even there was significant difference compared with controls,the heart function and serum level of tumour necrosis factor-alpha,interleukin-6 and 8 of patients with refractory heart failure were improved significantly after loading dose infusion of Milrinone.[Conclusion]Milrinone could improve the heart function and decrease the levels of tumour necrosis factor-alpha,interleukin-6 and 8. |
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| Keywords: | heart failure congestive/BL milrinone/BL tumor necrosis factor/BL interleukin-6/BL interleukin-8/BL |
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