| 异位宁对实验性子宫内膜异位症大鼠的治疗作用 |
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| 引用本文： | 杨东霞,马文光,马宝璋,曲凡.异位宁对实验性子宫内膜异位症大鼠的治疗作用[J].山东中医杂志,2006,25(4):262-264. |
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| 作者姓名： | 杨东霞 马文光 马宝璋 曲凡 |
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| 作者单位： | 1. 黑龙江中医药大学,黑龙江,哈尔滨,150040
2. 黑龙江中医药大学附属第一医院,黑龙江,哈尔滨,150040 |
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| 摘 要： | 目的:探讨异位宁治疗子宫内膜异位症的作用机制。方法:采用大鼠自体子宫内膜移植建立实验性子宫内膜异位症模型,分别观察异位宁和达那唑对模型大鼠外周血清白介素2(IL2)、白介素10(IL10)、雌二醇(E2)、孕酮(P)含量及血管内皮细胞生长因子(VEGF)在大鼠异位内膜组织中表达的影响。结果:异位宁对上述指标均有不同的下调或抑制作用,与模型组比较有显著性差异(P<0.05),异位宁高剂量组与达那唑相比无显著性差异(P>0.05)。结论:异位宁具有调节免疫、内分泌及血管内皮细胞生长因子作用,能够有效抑制异位子宫内膜的种植。
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| 关 键 词： | 子宫内膜异位症 异位宁 雌二醇 孕酮 白介素-2 白介素-10 血管内皮细胞生长因子 大鼠 |
| 文章编号： | 0257-358X（2006）04-0262-03 |
| 收稿时间： | 2006-01-09 |
| 修稿时间： | 2006年1月9日 |
Effect of Yiweining on rats with experimental endometriosis |
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| YANG Dong-xia,MA Wen-guan,MA Bao-zhang,QU Fan.Effect of Yiweining on rats with experimental endometriosis[J].Shandong Journal of Traditional Chinese Medicine,2006,25(4):262-264. |
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| Authors: | YANG Dong-xia MA Wen-guan MA Bao-zhang QU Fan |
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| Institution: | 1. Heilongjiang University of Traditional Chinese Medicine, Haerbin 150040, China; 2. First Affiliated Hospital, Heilongiiang University of Traditional Chinese Medicine, Haerbin 150040, China |
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| Abstract: | Objective: To study the effect and mechanism of Yiweining on treatment of endometriosis. Methods: To set up endometriosis model by rat self-endometria transplantation, IL-2、IL-10、E_2、P of serum and VEGF of endometriosis tissue were detected. Results: The five parameters were depressed by Yiweining. There was significant difference of each target between Yiweining group and model group(P<0.05). There was no significant difference of each target between the high dose of Yiweining group and Danazol group (P>0.05). Conclusion: Yiweining can inhibit the growth of endometrial transplants, which is relates with the VEGF of dometriotic tissue and serum cytokines and hormone. |
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| Keywords: | endometriosis Yiweining E_2 P IL-2 IL-10 vascular endothelial growth factor rat |
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