| 鼻咽癌细胞系CNE-2Z放射敏感性异质性与凋亡的关系 |
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| 引用本文： | 袁健,孙宁.鼻咽癌细胞系CNE-2Z放射敏感性异质性与凋亡的关系[J].实用肿瘤杂志,2005,20(3):210-212. |
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| 作者姓名： | 袁健 孙宁 |
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| 作者单位： | 1. 广东药学院病理学教研室,广东,广州,510000
2. 广东医学院病理学教研室,广东,湛江,524023 |
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| 摘 要： | 目的评估人鼻咽癌细胞系CNE-2Z放射敏感性异质性与凋亡敏感性的相关性。方法用流式细胞仪、荧光显微镜、电镜、Western-blot检测H5和S1凋亡能力的不同及凋亡相关蛋白表达的差异。结果H5、S1两种细胞的凋亡率均随着照射后时间的延长而增加,但H5比S1高且差异有显著性(P<0.05)。结论人鼻咽癌细胞系CNE-2Z放射敏感性的异质性,与细胞受射线照射后凋亡呈正相关,对射线敏感的亚细胞系凋亡率高。
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| 关 键 词： | 鼻咽肿瘤 癌基因 辐射耐受性 凋亡 |
| 文章编号： | 1001-1692(2005)03-0210-03 |
| 修稿时间： | 2004年3月3日 |
Relationship between radiosensitive heterogeneity and apoptosis of the nasopharyngeal carcinoma cell line CNE-2Z |
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| YUAN Jian,SUN Ning.Relationship between radiosensitive heterogeneity and apoptosis of the nasopharyngeal carcinoma cell line CNE-2Z[J].Journal of Practical Oncology,2005,20(3):210-212. |
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| Authors: | YUAN Jian SUN Ning |
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| Institution: | YUAN Jian~1,SUN Ning~2 |
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| Abstract: | Objective To assess the relationship between radiosensitive heterogeneity and the apoptosis of human nasopharyngeal carcinoma (NPC) cell line CNE-2Z. Methods Flow cytometry, fluorescence microscopy and Western-blot were used to detect the apoptosis and apoptosis-related protein expression in subtypes H5 and S1 of NPC CNE-2Z cell line after radiation. Results The apoptosis rate of H5 and S1 cells increased with extension of after-irradiation time, but H5 had a higher apoptosisrate than S1 and the difference was of statistical significance (P<0.05).Conclusion The radiosensitive heterogeneity of human NPC cell line CNZ-2Z is positively correlated to the apoptosis of cells after irradiation. |
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| Keywords: | nasopharyngeal neoplasms oncogenes radiation tolerancy apoptosis |
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