Ti gamma A + delta TCS1+ T cells in human thymus. Analysis of the T cell receptor. |
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| Authors: | R Bosse H Heiken W Kolanus P Delany F Triebel R E Schmidt |
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| Affiliation: | Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule, Hannover, FRG. |
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| Abstract: | TcR1+ T cells in peripheral blood have been shown to express in an exclusive fashion either the Ti gamma A or the delta TCS1 epitope. Here, we characterize a subset of TcR1+ T cells in fresh thymus co-expressing the Ti gamma A and delta TCS1 epitopes. TcR1dim and TcR1bright clones can be distinguished. Biochemical and molecular studies on both types of clones generated from these thymocytes reveal a unique T cell receptor structure characterized by the use of a V gamma 9/C gamma 2-encoded 55-kDa gamma chain nondisulfide linked to a V delta 1-encoded delta chain. |
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