Placental gene expression of the placental growth factor (PlGF) in intrauterine growth restriction |
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| Authors: | József Gábor Joó János Rigó Jr. Balázs Börzsönyi Csaba Demendi László Kornya |
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| Affiliation: | 1. First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary,;2. Second Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary, and;3. Szent István and Szent László Hospitals Budapest, Budapest, Hungary |
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| Abstract: | Objective: We analyzed changes in gene expression of placental growth factor (PIGF) in human placental samples obtained postpartum from pregnancies with IUGR.Methods: During a twelve-month study period representing the calendar year of 2012 placental samples from 101 pregnancies with IUGR and from 140 normal pregnancies were obtained for analysis of a potential difference in PIGF gene expression.Results: There was no significant difference in gene activity of the PIGF gene between the IUGR versus normal pregnancy groups (Ln2α: 0.92; p?α: 0.72; p?=?0.05). Placental PIGF gene activity was significantly lower in fetuses with more severe IUGR versus less severe cases (Ln2α: ?1.49; p?Conclusion: We found no difference in gene expression of PIGF in placental samples obtained from IUGR pregnancies versus normal pregnancy suggesting the absence of a direct role of PIGF gene activity in the development of defective angiogenesis in IUGR during the later stages of gestation. However, in more severe cases of intrauterine growth restriction PIGF expression does show a significant decrease indicating its potential role in the profound defect in angiogenesis in these cases. |
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| Keywords: | PIGF gene expression placenta placental growth factor intrauterine growth restriction |
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