THE INFLUENCE OF CIMETIDINE ON PEPTIC ULCER IN PATIENTS WITH ARTHRITIS TAKING ANTI-INFLAMMATORY DRUGS |
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| Authors: | DAVIES, JOAN COLLINS, A. J. DIXON, A. ST. J. |
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| Affiliation: | 1Royal National Hospital for Rheumatic Diseases, Bath BAI IRL Bath, UK
2Pharmacology Group, University of Bath Bath, UK |
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| Abstract: | Patients with arthritis who take nonsteroidal anti-inflammatorydrugs (NSAIDs) often develop peptic ulceration. Withdrawal ofthe NSAID may lead to increased debility and thus it may bedesirable to continue the NSAID while attempting to heal theulceration by additional therapeutic measures. We have investigatedthe effect of cimetidine in this role. Patients with gastroscopically-provenpeptic ulcer associated with NSAID ingestion were given eithercimetidine or placebo treatment while continuing to take theirNSAIDs. It was found that the ulceration healed in some patientsover a 6-week period even on placebo treatment. There was nostatistical difference found between the healing of these ulcerswhen compared with the cimetidine-treated group. The mechanismof NSAID-induced ulceration and the reason for the above findingis discussed. |
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