Dizocilpine-induced accuracy deficits in a visual signal detection task are not present following D-cycloserine administration in rats |
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Authors: | Howe W Matthew Burk Joshua A |
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Affiliation: | Department of Psychology, The College of William and Mary, Williamsburg, VA 23187, United States. |
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Abstract: | The N-methyl-D-aspartate (NMDA) receptor system is thought to be underactive in schizophrenia which may contribute to attentional dysfunction in this disease. In a visual signal detection task that required discrimination of signaled-trials from trials with no signal, the NMDA receptor antagonist, dizocilpine (0.05 mg/kg), increased errors on non-signal trials. Co-administration of dizocilpine and 10.0 mg/kg D-cycloserine, a co-agonist at the glycine site on the NMDA receptor, significantly decreased the error rate on non-signal trials compared to dizocilpine alone. These results suggest that drugs targeting the glycine site may be beneficial for attenuating attentional deficits associated with an underactive NMDA receptor system. |
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