| 他汀类药物多效药理作用及其机制研究进展 |
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| 引用本文： | 赵心彬,倪敏,陶霞.他汀类药物多效药理作用及其机制研究进展[J].药学实践杂志,2013,31(1):19-21. |
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| 作者姓名： | 赵心彬 倪敏 陶霞 |
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| 作者单位： | 第二军医大学长征医院药学部, 上海 200003,第二军医大学长征医院药学部, 上海 200003,第二军医大学长征医院药学部, 上海 200003 |
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| 摘 要： | 他汀类是临床上治疗高胆固醇血症主要药物, 广泛应用于冠心病一级及二级预防。近年来研究表明,他汀类药物还具有降脂外的多重作用,包括改善血管内皮功能、抗炎症、抗氧化作用、稳定动脉粥样硬化和抗肿瘤作用等。本文围绕他汀类药物对血管疾病和肿瘤的作用及机制展开综述。
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| 关 键 词： | 他汀类药物 血管疾病 肿瘤 |
| 收稿时间： | 2012/2/14 0:00:00 |
| 修稿时间： | 4/5/2012 12:00:00 AM |
Progress on the multiple pharmacological activity and mechanism of statins |
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| ZHAO Xin-bin,NI Min and TAO Xia.Progress on the multiple pharmacological activity and mechanism of statins[J].The Journal of Pharmaceutical Practice,2013,31(1):19-21. |
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| Authors: | ZHAO Xin-bin NI Min and TAO Xia |
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| Institution: | Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China,Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China and Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China |
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| Abstract: | Statins were a mainstay in the treatment of hyperlipidemia and used in the primary and secondary prevention of coronary artery disease. Recent studies indicated that there were some cholesterol-independent or pleiotropic effects of statins, including improving endothelial function, decreasing oxidative stress, inhibiting inflammation, enhancing the stability of atherosclerotic plaques and used for anticancer therapy. The effects and mechanisms of statins on vascular disease and cancer were reviewed in this paper. |
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| Keywords: | statins vascular disease cancer |
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