Histamine dependent cyclic AMP generating system in rabbit CNS: interaction with neuroregulators and forskolin |
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| Authors: | B Sek A Sebastjanska J Z Nowak |
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| Affiliation: | Department of Biogenic Amines, Polish Academy of Sciences, Lód?. |
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| Abstract: | Histamine (HI) potently stimulated, through H2-receptors, cAMP accumulation in rabbit cerebral cortical slices but not in retinal pieces. The action of HI in the cerebral cortex was not significantly affected by dopamine, serotonin, melatonin and GABA-ergic drugs. Forskolin markedly stimulated cAMP accumulation both in the cerebral cortex and retina. There was a synergistic interaction between HI and forskolin in the cerebral cortex, whereas in the retina HI decreased the forskolin-activated cAMP accumulation. |
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