清肺承气颗粒对大肠腑实证合并ALI/ARDS患者肺功能与肠功能的影响

目的:评价清肺承气颗粒对大肠腑实证合并ALI/ARDS患者的肺功能和肠功能的影响,以及肠功能与肺功能之间的相关性。方法:采用前瞻性、多中心、随机、双盲、对照的实验设计方法,从2009年8月至2013年7月,在5个中心入选符合大肠腑实证表现的腹部疾患合并肺损伤的患者207例。随机分为西医常规治疗对照组、通里攻下治疗组。对照组给予西医常规综合治疗,通里攻下治疗组在对照组基础上加用通里攻下药物清肺承气颗粒。观察两组患者治疗前、治疗1 d、3 d、7 d的氧合指数、L/M,治疗前、治疗后7 d的APACHEⅡ评分,治疗7 d后病死率。结论:清肺承气颗粒治疗大肠腑实证表现的腹部疾患所致肺损害患者,能改善患者的氧合指数、肠屏障功能,降低病死率,并证实肺功能的改善与肠功能的改善密切相关,通过治疗作用证实了"肺与大肠相表里"的密切关系。

Effect of Qingfeichengqi Granules on Lung and Bowel Function of Patients with Bowel Repletion and ALI/ARDS

Objective：To evaluate the effect of Qingfeichengqi granules on the lung and bowel function of patients with bowel repletion and ALI/ARDS, as well as the relevance between the lung function and bowel function .Methods： A prospective, multi-center, ran-dom, double minded and controlled trial was conducted .Two hundred and seven patients who had abdominal diseases manifested with yangming bowel repletion and lung damage treated in the 5 centers from August 2009 to July 2013 were include and randomly divided in-to treatment group and control group .Patients in the treatment group were given conventional western medicine treatment , and treatment group gave patients extra application of Qingfeichengqi granules .The oxygen index , L/M, APACHE II score before treatment and 7 days after treatment, as well as mortality rate after 7days of treatment were observed .Conclusion：Qingfeichegnqi granules treating patients with abdominal diseases manifested with yangming bowel repletion and lung damage can improve the oxygen rate and bowel function , de-crease mortality , and verify the close relevance between lung function and bowel function so that prove the “exterior-interior relation be-tween lung and large intestine”.