| 益母草对硫酸镉诱发的小鼠骨髓细胞微核率的影响 |
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| 引用本文： | 庞慧民,朱玉琢,刘念稚.益母草对硫酸镉诱发的小鼠骨髓细胞微核率的影响[J].吉林大学学报(医学版),2002,28(5):463-464. |
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| 作者姓名： | 庞慧民 朱玉琢 刘念稚 |
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| 作者单位： | 1. 吉林大学基础医学院医学遗传学教研室,吉林长春,130021;2. 吉林省人民医院 |
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| 基金项目： | 吉林省科技发展计划;20010529; |
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| 摘 要： | 目的:观察中草药益母草对硫酸镉引起的小鼠骨髓细胞遗传物质损伤的防护作用.方法:采用小鼠骨髓嗜多染红细胞微核试验.结果:镉可以诱发小鼠骨髓细胞产生微核;益母草本身不能诱发微核,但能使诱发的微核率明显降低.结论:益母草对硫酸镉引起的遗传物质损伤具有防护作用,即抗诱变作用.
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| 关 键 词： | 硫酸镉 微核 抗诱变 益母草 |
| 文章编号： | 1671-587X(2002)05-0463-02 |
| 修稿时间： | 2002年1月8日 |
Effect of Herba leonuri on the micronucleus frequencies induced by CdSO4 in the bone marrow cells of mice |
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| PANG Hui min l,ZHU Yu zhuo ,LIU Nian zhi.Effect of Herba leonuri on the micronucleus frequencies induced by CdSO4 in the bone marrow cells of mice[J].Journal of Jilin University: Med Ed,2002,28(5):463-464. |
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| Authors: | PANG Hui min l ZHU Yu zhuo LIU Nian zhi |
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| Institution: | PANG Hui min l,ZHU Yu zhuo 1,LIU Nian zhi 2 |
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| Abstract: | Objective:To observe the preventive effect of Herba leonuri on genetic damage induced by CdSO 4 in the bone marrow cells of mice. Methods:The micronucleus test (MNT) of mouse bone marrow cells was used in the study. Results:CdSO 4could induce micronucleus formation in the bone marrow cells of mice and Herba leonuri could decrease strikingly micronuclei frequencies induced by CdSO 4. Conclusion:Herba leonuri may protect the genetic materials from injury caused by CdSO 4,namely, showing effective antimutagenesis. |
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| Keywords: | CdSO 4 micronucleus formation antimutagenesis Herba leonuri |
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