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| 带状疱疹患者CD_4~+T淋巴细胞亚群的检测 | |
| 引用本文： | 张美芳,马静,杨励,张洁,张小艳.带状疱疹患者CD_4~+T淋巴细胞亚群的检测[J].中国皮肤性病学杂志,2009,23(4). |
| 作者姓名： | 张美芳 马静 杨励 张洁 张小艳 |
| 作者单位： | 1. 陕西省人民医院皮肤科,陕西,西安,710068 2. 广东省第二人民医院皮肤科,广东,广州,510150 3. 陕西省人民医院中心实验室,陕西,西安,710068 |
| 摘 要： | 目的通过观察带状疱疹患者T细胞亚群的变化,分析机体免疫功能与患带状疱疹的相关性,揭示带状疱疹发病的规律和机理。方法采用流式细胞仪技术检测73例不同年龄和性别的带状疱疹患者T细胞亚群的分布情况,并选择88例健康体检者做为健康对照。结果带状疱疹患者血清CD4+T细胞显著降低,CD3+T细胞降低,CD8+T细胞升高,CD4/CD8比值有所下降;不同年龄和不同病程的患者间也存在T细胞亚群的明显差异。结论带状疱疹患者存在CD4+T细胞的降低和T细胞亚群免疫功能下降,其在带状疱疹的发生和发展中可能起重要作用;老年人是带状疱疹发病的危险人群。 |
| 关 键 词： | 带状疱疹 T细胞亚群 CD4+T细胞 |
Depection of Serum CD+4 T Cell and T- lymphocyte Subsets in Patients of Herpes Zoster |
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| ZHANG Mei-fang,MA Jing,YANG Li,ZHANG Jie,ZHANG Xiao-yan.Depection of Serum CD+4 T Cell and T- lymphocyte Subsets in Patients of Herpes Zoster[J].The Chinese Journal of Dermatovenereology,2009,23(4). | |
| Authors: | ZHANG Mei-fang MA Jing YANG Li ZHANG Jie ZHANG Xiao-yan |
| Abstract: | Objective To analyse the relationship between virus infection and immune function and indicated the rule and mechanism in pathogenesis of herpes zoster by investigating the change of T-lymphocyte subsets. Methods T-lymphocyte subsets were detected by flow cytometry( FCM) in patients with herpes zoster in different ages. Results Decrease of CD+3,CD+4 and CD4/ CD8 ration were found in HZ group as compared to that of the controls. But,increase of CD+8 was found in HZ group than in that of the controls. In different age and course of patients,the level of CD+3,CD+4,CD+8 and CD4/CD8 ration remained different from those in controls. Conclusions These results indicated that the T cellular immunity in HZ patients was impaired and suggested that T cellular immunity may play a great role in the pathogenesis and development of herpes zoster. Elder people are the risk population. |
| Keywords: | Herpes zoster T-lymphocyte subsets CD+4T cell |
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