中药栀黄滴眼液联合素高捷治疗干眼症临床疗效观察

目的] 探讨中药局部应用及中药联合角膜保护剂治疗干眼的临床疗效。方法] 临床确诊的干眼患者随机分为联合用药组和中药组。前者予素高捷眼用凝胶、中药栀黄滴眼液，后者单纯应用栀黄滴眼液。观察患者用药前后临床症状、泪膜破裂时间（BUT）、泪液分泌量（Schirmer法）等指标变化。结果] 1） 两组治疗前后比较泪液分泌均有改善，且两组间比较差异无统计学意义。2） 两组治疗前后BUT均显着改善，联合用药组改善更为明显。3）联合用药组总有效率为92.68%，中药组总有效率为73.17%.两组疗效比较差异有统计学意义。结论] 中药栀黄滴眼液可使干眼患者泪液分泌增加、BUT延长。栀黄眼液在改善泪液分泌方面效果与联合素高捷组无统计学差异，而在改善BUT方面联合应用素高捷组优于单用栀黄滴眼液效果。

Clinical effect of Zhihuang eye drops combined with Solcoseryl on dry eye syndrome

Objective] To investigate the clinical effect of local application of Chinese medicine and Chinese medicine combined with corneal protective agent in treating dry eye. Methods] Clinically diagnosed patients with dry eye were randomly divided into combined treatment group and Chinese medicine only group. The former was given Solcoseryl eye gel and Zhihuang eye drops and the latter was given Zhihuang eye drops only. The clinical symptoms in patients before and after treatment, breakup time tear film (BUT), tear secretion (Schirmer act) were observed. Results] 1)The tear secretion before and after treatment were improved in both groups and without significant difference between them. 2)The breakup time tear film (BUT) before and after treatment improved in both groups, but more significant improvement was found in combined treatment group. 3)The total effective rate was 92.68% in combined treatment group and 73.17% in Chinese medicine group only with significant difference between these two groups. Conclusion] Zhihuang eye drops can help patients with dry eye in increasing tear secretion as well as the breakup time tear film. It has no significant difference in improving patients'' tear secretion in Zhihuang eye drops when compared with Zhihuang eye drops combined Solcoseryl. The effect of Zhihuang eye drops alone in improving BUT is worse than the combined treatment with Solcoseryl.