| 牛磺酸纳米乳的制备及稳定性考察 |
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| 引用本文： | 李振化,李祥,赵振宇,张韻慧.牛磺酸纳米乳的制备及稳定性考察[J].天津中医药大学学报,2015,32(6):372-375. |
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| 作者姓名： | 李振化 李祥 赵振宇 张韻慧 |
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| 作者单位： | 天津市中医药研究院附属医院, 天津 300120,天津市中医药研究院附属医院, 天津 300120,天津市中医药研究院附属医院, 天津 300120,天津大学药物科学与技术学院, 天津 300072 |
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| 基金项目： | 天津市卫生局科技基金项目(05kyz02)。 |
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| 摘 要： | 目的] 研究牛磺酸纳米乳的处方、制备及稳定性考察。方法] 通过滴定法绘制伪三元相图,根据相图优选处方,并初步考察牛磺酸纳米乳的稳定性、粒径分布和理化性质。结果] 确定纳米乳处方为十四酸异丙酯(IPM):司盘-80:吐温-80:水=4:4:6:1.牛磺酸纳米乳平均粒径为30.8 nm.结论] 牛磺酸纳米乳制备方法简单,性质稳定。
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| 关 键 词： | 牛磺酸 纳米乳 伪三元相图 稳定性 |
| 收稿时间： | 2015/2/17 0:00:00 |
Preparation and stability of taurine nanoemulsion |
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| LI Zhen-hu,LI Xiang,ZHAO Zhen-yu and ZHANG Yun-hui.Preparation and stability of taurine nanoemulsion[J].Journal of Tianjin University of Traditonal Chinese Medicine,2015,32(6):372-375. |
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| Authors: | LI Zhen-hu LI Xiang ZHAO Zhen-yu and ZHANG Yun-hui |
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| Affiliation: | Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China,Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China,Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China and School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China |
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| Abstract: | Objective] To study the optimum formulation and preparation and stability of taurine nanoemulsion. Methods] The optimum formulation was investigated by using titration to prepare the pseudo-ternary phase diagram, testing the size distribution,stability and physico-chemical property of taurine nanoemulsion. Results] The optimum formulation was IPM:Span80:Tween80:water=4:4:6:1.The stability of taurine nanoemulsion was good, and average size was 30.8 nm.Conclusion] Taurine nanoemulsion is easy to prepare and has good stability. |
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| Keywords: | taurine nanoemulsion pseudo-ternary phase diagram stability |
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