| 糖脂清过柱前后对KK-Ay小鼠血糖血脂药效学影响对比实验 |
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| 引用本文： | 李玉红,刘虹,王茜,李俊青,曾森,张德芹,胡利民.糖脂清过柱前后对KK-Ay小鼠血糖血脂药效学影响对比实验[J].天津中医药大学学报,2012,29(4):384-388. |
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| 作者姓名： | 李玉红 刘虹 王茜 李俊青 曾森 张德芹 胡利民 |
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| 作者单位： | 天津中医药大学中医药研究院,天津市中药药理学重点实验室,方剂学教育部重点实验室,天津 300193;天津中医药大学中医药研究院,天津市中药药理学重点实验室,方剂学教育部重点实验室,天津 300193;天津中医药大学中医药研究院,天津市中药药理学重点实验室,方剂学教育部重点实验室,天津 300193;天津中医药大学中医药研究院,天津市中药药理学重点实验室,方剂学教育部重点实验室,天津 300193;天津中医药大学中医药研究院,天津市中药药理学重点实验室,方剂学教育部重点实验室,天津 300193;天津中医药大学中医药研究院,天津市中药药理学重点实验室,方剂学教育部重点实验室,天津 300193;天津中医药大学中医药研究院,天津市中药药理学重点实验室,方剂学教育部重点实验室,天津 300193 |
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| 基金项目： | 科技部国际科技合作项目(2009DFA31070). |
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| 摘 要： | 目的] 对比治疗2型糖尿病新药糖脂清经过大孔树脂处理与未经过大孔树脂(过柱前后)在降血糖、调节血脂药效学方面有无差异.方法] 应用糖尿病KK-Ay小鼠,大孔树脂处理前、后糖脂清8、4、2 g/kg灌胃给药5周,以拜唐苹为对照药,评价并比较过柱前、后糖脂清对小鼠血糖、血脂等的影响.结果] 糖脂清过柱复方与未过柱复方均有降低小鼠饮水量、尿量趋势；能显着降低小鼠非禁食及灌胃蔗糖后30、60、120 min血糖浓度,降低血清甘油三酯(TG)、胰岛素含量,改善胰岛素抵抗.结论] 糖脂清中山楂叶、丹参、赤芍经大孔树脂处理后没有降低整体药效.
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| 关 键 词： | 山楂叶 丹参 赤芍 大孔树脂 药效学 |
| 收稿时间： | 2012/3/10 0:00:00 |
Comparative experiment of TZQ on abnormal glucose and lipid metabolism in KK-Ay mice before and after passing macroporous resin |
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| LI Yu-hong,LIU Hong,WANG Qian,LI Jun-qing,ZENG Sen,ZHANG De-qin and HU Li-min.Comparative experiment of TZQ on abnormal glucose and lipid metabolism in KK-Ay mice before and after passing macroporous resin[J].Journal of Tianjin University of Traditonal Chinese Medicine,2012,29(4):384-388. |
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| Authors: | LI Yu-hong LIU Hong WANG Qian LI Jun-qing ZENG Sen ZHANG De-qin and HU Li-min |
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| Institution: | Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China;Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China;Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China;Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China;Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China;Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China;Tianjin Key Laboratory of Chinese Medical Pharmacology, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Institute of traditional Chinese medicine, Tianjin University of TCM,Tianjin 300193, China |
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| Abstract: | |
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| Keywords: | Hawthorn Leaf Danshen root Red Paeony Root macroporous resin pharmacodynamics |
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