平性活血化瘀中药物质基础与药理作用的研究进展

通过查阅《中国药典》2015年版搜集到37味平性活血化瘀中药,并利用中国知网检索其物质基础和药理作用的相关文献,整理和归纳其化学成分和药理作用。平性活血化瘀中药含有丰富的化学成分,主要包括黄酮、萜类、甾体、糖类等成分;同时,其具有抑制血小板聚集及抗血栓、抗动脉粥样硬化、抑制缺血再灌注损伤、抗肿瘤、抗纤维化、保肝护肝、抗炎镇痛、降压、调节免疫力等多种药理作用。平性活血化瘀中药应用广泛常用于治疗肝纤维化、心血管疾病、肝癌、子宫癌、高血压、高血脂等疾病。现随着人们对平性药的日益关注,平性活血化瘀中药的研究得到进一步深入,这为平性活血化瘀中药提供了更好的发展前景。目前,关于平性活血化瘀中药的研究主要集中在单一中药的药物化学成分与药理活性方面,而针对其药性的研究较少。作者从药物药性的角度出发,对活血化瘀中药药理作用及其物质基础进行系统的归纳和总结,可为平性活血化瘀中药的临床应用提供理论指导,为平性活血化瘀中药提供新的研究思路。

Pharmacological Effect and Substance Basis of Neutral Blood-activating and Stasis-removing Traditional Chinese Medicine

By reviewing the 2015 edition of Chinese Pharmacopoeia, the author collected 37 neutral blood-activating and stasis-removing traditional Chinese medicines. And by retrieving literatures on relevant material basis and pharmacological effects on CNKI, the author organized and summarized their chemical composition and pharmacological effects. Neutral blood-activating and stasis-removing traditional Chinese medicines are rich in chemical components, such as flavonoids, steroids and sugars. At the same time, it has a variety of pharmacological effects, including anti-platelet aggregation and anti-thrombotic mechanism, anti-atherosclerosis, inhibition of ischemia-perfusion injury, anti-tumor, anti-fibrosis, liver protection, anti-inflammatory analgesia, blood pressure reduction and immune regulation. It is widely used in the treatment of liver fibrosis, cardiovascular disease, liver cancer, uterine cancer, hypertension, hyperlipidemia and other diseases. Nowadays, as people has paid increasing attention to neutral herbs, studies on traditional Chinese medicines for activating blood circulation and removing blood stasis have been further deepened, which provides a better development prospect for neutral blood-activating and stasis-removing traditional Chinese medicines. From the perspective of medicinal properties, the authors systematically collected and summarized the pharmacological effects and material basis of neutral blood-activating and stasis-removing traditional Chinese medicines. This article provides theoretical guidance for the clinical application of neutral blood-activating and stasis-removing traditional Chinese medicines and new medicine research ideas for neutral blood-activating and stasis-removing traditional Chinese medicines.