| 麦角甾苷眼用固体脂质纳米粒制备及其体外释药的研究 |
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| 引用本文： | 佟玲,李志宝,陈静,刘志东,张莉,王宝成.麦角甾苷眼用固体脂质纳米粒制备及其体外释药的研究[J].天津中医药大学学报,2015,32(6):368-371. |
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| 作者姓名： | 佟玲 李志宝 陈静 刘志东 张莉 王宝成 |
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| 作者单位： | 天津中医药大学, 现代中药发现与制剂技术教育部工程中心, 天津 300193;天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193,通药制药集团股份有限公司, 通化 134000,天津中医药大学, 现代中药发现与制剂技术教育部工程中心, 天津 300193;天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193,天津中医药大学, 现代中药发现与制剂技术教育部工程中心, 天津 300193;天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193,天津中医药大学, 现代中药发现与制剂技术教育部工程中心, 天津 300193;天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 300193,通药制药集团股份有限公司, 通化 134000 |
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| 基金项目： | 教育部新世纪优秀人才支持计划(NCET-12-1068)。 |
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| 摘 要： | 目的] 研究麦角甾苷眼用固体脂质纳米粒的制备方法及其体外释放的情况。方法] 采用乳化蒸发-低温固化法制备麦角甾苷固体脂质纳米粒,超滤离心法测其包封率,并对其粒径、电位、进行进一步考察,用差示扫描量热仪(DSC)表征其性质,采用透析法考察固体脂质纳米粒中麦角甾苷的体外释放行为。结果] 麦角甾苷固体脂质纳米粒的平均粒径为85.56 nm,Zeta 电位约为-20.97 mV,药物平均包封率为88.31 %,DSC 表明其理化性质稳定可靠,体外12 h 累计释放率62.46 %。结论] 制备的麦角甾苷固体脂质纳米粒包封率较高,粒径小且分布均匀,有良好的缓释作用。
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| 关 键 词： | 麦角甾苷 固体脂质纳米粒 包封率 稳定性 体外释放 |
| 收稿时间： | 2014/12/27 0:00:00 |
Preparation of acteoside solid lipid nanoparticle and the in vitro release characteristics |
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| TONG Ling,LI Zhi-bao,CHEN Jing,LIU Zhi-dong,ZHANG Li and WANG Bao-cheng.Preparation of acteoside solid lipid nanoparticle and the in vitro release characteristics[J].Journal of Tianjin University of Traditonal Chinese Medicine,2015,32(6):368-371. |
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| Authors: | TONG Ling LI Zhi-bao CHEN Jing LIU Zhi-dong ZHANG Li and WANG Bao-cheng |
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| Institution: | Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Tongyao Pharmaceutical Group Stock Co., Ltd., Tonghua 134000, China,Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China and Tongyao Pharmaceutical Group Stock Co., Ltd., Tonghua 134000, China |
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| Abstract: | Objective] To study the preparation of acteoside solid lipid nanoparticle(SLN) and its in vitro release behavior. Methods] Emulsification-evaporation was appropriate for the preparation of acteoside solid lipid nanoparticle and entrapment efficiency was measured by ultrafiltration. The properties of SLN including mean diameter and Zeta potential were studied. The physical property was measured by DSC and the release property was studied by dialysis method. Results] Mean diameter and Zeta potential of prepared acteoside solid lipid nanoparticle were 85.56 nm and -20.97 mV. The mean drug entrapment efficiency was 88.31%. The physical property tested by the result of DSC was stability, and the in vitro accumulative release was 62.46% of the total drug. Conclusion] The acteoside SLN prepared in this study has high encapsulation efficiency and small size which has an even distribution and the in vitro release could be in a well sustained way. |
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| Keywords: | acteoside solid lipid nanoparticle entrapment efficiency stability in vitro release |
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