| 鹅掌楸苷和光甘草定协同抗氧化作用研究 |
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| 引用本文： | 冯倩茹,叶柳青,刘园园,龚又明,李红艳,王艳. 鹅掌楸苷和光甘草定协同抗氧化作用研究[J]. 天津中医药大学学报, 2016, 33(10): 624-628 |
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| 作者姓名： | 冯倩茹 叶柳青 刘园园 龚又明 李红艳 王艳 |
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| 作者单位： | 广东省中医院药学部, 广州 510120,天津中医药大学中药学院, 天津 300193,天津中医药大学中药学院, 天津 300193,广东省中医院药学部, 广州 510120,南开大学药学院, 天津 300071,天津中医药大学中药学院, 天津 300193 |
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| 基金项目： | 西青区科技型中小企业发展专项资金项目（XQKH2013-011）。 |
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| 摘 要： | [目的] 研究鹅掌楸苷和光甘草定协同抗氧化作用。[方法] 采用1，1-二苯基-2-苦苯肼（DPPH）和2，2-联氮-二（3-乙基-苯并噻唑-6-磺酸）二铵盐（ABTS）自由基清除实验，测定鹅掌楸苷和光甘草定单独及不同浓度配比的抗氧化活性，等辐射分析法（Isobologram）对协同作用结果进行分析。[结果] 鹅掌楸苷和光甘草定配比为3∶1时对DPPH自由基清除表现为协同作用，1:1表现为相加作用，1:3表现为拮抗作用。ABTS实验结果显示复配为1:1、1:3和3:1时均有协同作用，并且复配组合中协同作用强弱为：1:3> 1:1> 3:1。[结论] 鹅掌楸苷和光甘草定按一定比例复配后具有协同抗氧化作用。
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| 关 键 词： | 鹅掌楸苷 光甘草定 协同作用 抗氧化活性 |
| 收稿时间： | 2016-05-12 |
Study on synergistic antioxidant activities of Liriodendrin and Glabridin |
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| FENG Qian-ru,YE Liu-qing,LIU Yuan-yuan,GONG You-ming,LI Hong-yan and WANG Yan. Study on synergistic antioxidant activities of Liriodendrin and Glabridin[J]. Journal of Tianjin University of Traditonal Chinese Medicine, 2016, 33(10): 624-628 |
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| Authors: | FENG Qian-ru YE Liu-qing LIU Yuan-yuan GONG You-ming LI Hong-yan WANG Yan |
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| Affiliation: | Pharmaceutical Department of Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China,School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Pharmaceutical Department of Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120, China,College of Pharmacy, Nankai University, Tianjin 300071, China and School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China |
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| Abstract: | [Objective] To evaluate the synergistic antioxidant activities of Liriodendrin and Glabridin. [Methods] The DPPH and ABTS radicals scavenging assay were established to detect the synergistic antioxidant activities of components. Isobologram method was also established to study the synergistic result. [Results] There was a synergistic antioxidant effect between Liriodendrin and Glabridin in DPPH radicals scavenging assay when the mass ratio was 3:1, addictive effect when the mass ratio was 1:1 and antagonistic effect when the mass ratio was 1:3. There was a synergistic antioxidant effect between Liriodendrin and Glabridin in ABTS radicals scavenging assay when the mass ratio was 3:1, 1:1 and 1:3. And the synergistic antioxidant effect was 1:3> 1:1> 3:1. [Conclusion] There was a synergistic antioxidant effect between Liriodendrin and Glabridin according to a certain proportion of compound. |
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| Keywords: | Liriodendrin Glabridin synergistic effect antioxidant activity |
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