苄星青霉素治疗妊娠期梅毒对妊娠结局的影响

目的评价苄星青霉素治疗妊娠期梅毒的疗效，及治疗后对妊娠结局的影响。方法回顾性分析2002年1月至2012年1月在我院发现的妊娠合并梅毒患者资料，通过查阅病历是否进行青霉素抗梅毒治疗将患者分为治疗组与对照组，比较两组患者的妊娠结局。结果治疗组的不良妊娠结局明显低于对照组，足月儿与正常儿明显高于对照组，两组相比差异有统计学意义（P〈0．05），不同孕周进行抗梅毒治疗效果差异明显，以早孕组治疗效果最佳，不良妊娠结局率最低，与中孕组与晚孕组相比差异有统计学意义（P〈0．05）。结论妊娠合并梅毒进行苄星青霉素治疗后的不良妊娠结局明显低于未治疗组，首次青霉素治疗的早晚与妊娠结局、围产儿预后相关，越早进行治疗效果越明显。

Effect of benzathine penicillin for pregnant women with syphilis on pregnancy outcomes

Objective To explore the efficacy of benzathine penicillin in the treatment of syphilis in pregnant women and the effect of this therapy on pregnancy outcomes. Methods The data on pregnant women with syphilis who had been diagnozed in our hospital during the period of January 2002 to January 2012-01 were retrospectively analyzed. The women were divided into study group and control group aeeroding to administration of benzathine penicillin. The pregnancy outcomes were compared between the two groups. Results The rate of adverse pregnancy outcomes was markedly lower in the study group than in the control group. The rates of full-term infants and healthy infants were significantly higher in the study group than in the control group, with statistical significances （ P〈 0.05 ）. The efficacy of anti-syphilis treatment differed signifi- candy at different weeks of gestational age, with a best efficacy and a lowest rate of adverse in the group of first trimester, which was a statistical significance as compare with the group of second trimester or third trimester（ P 〈 0.05 ）. Conclusions The rate of adverse pregnancy outcomes is markedly lower in the pregnant women with syphilis undergoing benzathine penicillin. The timing of initial therapy with benzathine penicillin is associated with the pregnant outcomes the ealier the administration of the therapy, the better the efficay.