Preparation and evaluation of a chitosan-coated antioxidant liposome containing vitamin C and folic acid |
| |
| Authors: | Zhen Jiao Xiudong Wang Yuting Yin Jingxin Xia Yanan Mei |
| |
| Affiliation: | 1. School of Chemistry and Chemical Engineering, Southeast University, Nanjing, China;2. Center for Nanobiotechnology, Joint Research Institute of Southeast University and Monash University, Suzhou, China;3. School of Chemistry and Chemical Engineering, Southeast University Chengxian College, Nanjing, China |
| |
| Abstract: | Vitamin C (VC) and folic acid (FA) are the important nutrient and antioxidant in human body. In order to improve their stability, their co-loaded liposomes (VCFA-Lip) and chitosan-coated liposomes (CS-VCFA-Lip) are prepared and characterised. The mean particle size of VCFA-Lip and CS-VCFA-Lip is 138?nm and 249?nm, respectively. The encapsulation efficiencies of both drugs for CS-VCFA-Lip are much higher than those for VCFA-Lip. Furthermore, the experimental results show that the antioxidant activity of CS-VCFA-Lip is higher than that of VCFA-Lip. Moreover, the storage stability study reveals that the chitosan coating can efficiently improve the physical stability of VCFA-Lip. These results indicate that stability of VC and FA can be greatly improved after being wrapped by liposomes. In addition, the performance of CS-VCFA-Lip is better than VCFA-Lip, indicating CS-VCFA-Lip can be applied as a promising delivery system for the antioxidant defence system to the food industry and cosmetic industry. |
| |
| Keywords: | Vitamin C folic acid co-loaded antioxidant liposomes chitosan antioxidant activity |
|
|
