孟鲁司特预防毛细支气管炎反复喘息89例临床观察

目的探讨孟鲁司特对毛细支气管炎患儿预后的影响。方法选择2006年6月至2007年11月住院的毛细支气管炎患儿89例，随机分为治疗组（46例）和对照组（43例），两组患儿均给予布地奈德混悬液、万托林、爱喘乐雾化液吸入等综合措施，治疗组在上述基础上加用孟鲁司特4mg，每晚1次，口服，治疗3个月，随访1年。观察急性期两组患儿喘憋、肺部啰音、咳嗽、住院天数、血清总IgE情况及了解孟鲁司特对患儿反复喘息发生的影响。结果治疗组的观察指标明显优于对照组，随访1年，治疗组再次喘息的机率明显低于对照组（P值〈0．05）。结论毛细支气管炎患儿临床缓解后继续长疗程（3个月）口服孟鲁司特可减少喘息复发，有利于毛细支气管炎预后及支气管哮喘的早期干预。

Clinical observation of the montelukast for preventing the repeated gasp because of bronchiolitis

Objective To explore the prognostic effect of montelukast on children patients with bronchiolitis.Methods 89 children patients with bronchiolitis in our hospital during the time from June 2006 to Nov 2007 were randomly divided into two groups treatment group and control group.Based on the treatment of budesonide suspl,Ventolin,and atomization inhalation.treatment group (46 patients) and control group (43) were administrated respectively with or without montelukast (4 mg for oral use at every night) for 3 mo...