| 细胞因子和糖尿病心肌病 |
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| 引用本文： | 王永健,宋作珪. 细胞因子和糖尿病心肌病[J]. 国际内分泌代谢杂志, 2006, 29(1): 57-59,72. DOI: 10.3760/cma.j.issn.1673-4157.2009.s1.019 |
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| 作者姓名： | 王永健 宋作珪 |
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| 作者单位： | 浙江大学医学院附属第二医院内分泌科,310009; |
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| 摘 要： | Diabetic cardiomyopathy (DCM), as an independent diabetic cardiac complication, has been paid more attention to. In clinical study, DCM was characterized by left ventricular diastolic dysfunction at the early stage. The pathogenesis of DCM is characterized by myocyte hypertrophy and cardiac fibrosis,ex-tracellular matrix accumulation and deposition. The development of DCM is multifactorial, the mechanism is still unclear. Several mechanisms are involved in the pathogenesis of DCM including myocardial fibrosis,in-terstitial inflammation and endothelial dysfunction. Cytokines can involve in multiple pathophysiological processes. In this review, the relationships between transforming growth factor-β1, connective tissue growth factor, tumor necrosis factor-α, insulin-like growth factor-1 ,adiponectin ,thrombospondin-1 and DCM are sum-marized. It may be the basis of therapeutic approaches for ameliorating DCM.
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| 关 键 词： | 细胞因子 转化生长因子β1 结缔组织生长因子 肿瘤坏死因子-α 糖尿病心肌病 Transformiag growth factor-β1 |
Cytokines and diabetic cardiomyopathy |
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| WANG Yongjian,SONG Zuo-gui. Cytokines and diabetic cardiomyopathy[J]. International JOurnal of Endocrinology and Metabolism, 2006, 29(1): 57-59,72. DOI: 10.3760/cma.j.issn.1673-4157.2009.s1.019 |
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| Authors: | WANG Yongjian SONG Zuo-gui |
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| Abstract: | |
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| Keywords: | CytokineConnective tissue growth factorTumor necro-sis factor-aDiabetic cardiomyopathy |
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