大豆异黄酮对非酒精性脂肪肝病大鼠的作用

目的探讨大豆异黄酮对高脂饮食诱导大鼠非酒精性脂肪肝病模型的干预作用。方法将50只SD大鼠随机分成5组:正常组,模型组,大豆异黄酮低剂量组(30mg/kg/d),大豆异黄酮中剂量组(100mg/kg/d),大豆异黄酮高剂量组(300mg/kg/d)。除正常组外,其余各组以高脂饮食诱导建立大鼠脂肪肝模型,测定大鼠血清中总胆固醇(TC)、甘油三酯(TG)含量,计算肝指数,对肝脏进行病理学检查,观察大豆异黄酮对该模型的影响。结果模型组大鼠血清中甘油三酯(TG)、胆固醇(TC)水平明显高于正常组(P<0.01);与模型组相比,SI高剂量组及中剂量组大鼠血清中TG、TC水平和肝指数水平均明显低于模型组(P<0.05),SI高剂量组及中剂量组大鼠肝组织的病理损伤明显改善。结论大豆异黄酮对高脂饮食诱导的大鼠脂肪肝有明显的干预作用。

Effects of soybean isoflavones on the nonalcoholic fatty liver diseases in rats

Objective To evaluate the protective effects of soybean isoflavones（SI） on hyperlipidmi-induced fatty liver in rats. Method 50 SD rats were randomly divided into 5 groups： nomal control group, model group, low dose of SI （ 30mg/kg/d ） treatment group, intermediate dose of SI （ 100mg/kg/d ） treatment group and high dose of SI （ 300mg/kg/d ） treatment group. The fatty liver model of rats were induced by oral administration of high fat diet. The contents of triglyceride （TG） and total cholesterol （TC） in serum were measured and liver index was calculated. Histopathologic examination of the liver tissues was also performed. Results There was a significant increase of serum TG and TC levels in model group compared with normal control group （P〈0.01）, but decreased in IS treatment groups compared with model group （P〈0.05）. The liver index was significantly reduced in IS treatment groups compared with model group （P〈0.05）. SI also markedly ameliorated the pathological injury in the liver tissue. Conclusion Soybean isoflavones exerts a significant protective effect on hyperlipidmi -induced fatty liver in rats.