Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China, 2011 |
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Authors: | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia LI Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong |
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Affiliation: | [1]Collabroative Innovation Center for Diagnosis Treatment of Infectious Disease, State Key Laboratory forInfectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention, Beijing 102206, China [2]Chaoyang District Center forDisease Control and Prevention, Beijing 100021, China [3]Harbin Municipal Center for Disease Control andPrevention, Harbin 150056, Heilongjiang, China [4]Office of Disease Control and Emergency Response, ChineseCenter for Disease Control and Prevention, Beijing 102206, China [5]Suzhou City Center for Disease Control andPrevention, Suzhou 215004, Jiangsu, China |
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Abstract: | ObjectiveTo investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.MethodsSeventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011. Emm genotyping, pulsed-field gel electrophoresis (PFGE), superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.ResultsA total of 4 different emm types were identified. Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles. Emm12 (79.7%) and emm1 (14.9%) accounted for approximately 94% of all the isolates. The speA gene was all negative in emm12 isolates and positive in emm1 isolates. All strains were resistant to erythromycin, and 89.4% of them were resistant to erythromycin, tracycline, and clindamycin simultaneously.ConclusionSeveral highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains, though no new emm type was found in this outbreak. The data provide a baseline for further surveillance of scarlet fever, which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. |
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Keywords: | Scarlet fever Streptococcus pyogenes Molecular epidemiology |
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