| Maspin、P53、Skp2蛋白在结直肠肿瘤中的表达及其意义 |
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| 引用本文： | 倪江涛,易永芬,石海鹏.Maspin、P53、Skp2蛋白在结直肠肿瘤中的表达及其意义[J].重庆医科大学学报,2010,35(1). |
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| 作者姓名： | 倪江涛 易永芬 石海鹏 |
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| 作者单位： | 重庆医科大学病理教研室分子医学及肿瘤研究中心,重庆,400016;重庆医科大学病理教研室分子医学及肿瘤研究中心,重庆,400016;重庆医科大学病理教研室分子医学及肿瘤研究中心,重庆,400016 |
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| 基金项目： | 重庆市教委科研基金资助 |
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| 摘 要： | 目的:研究maspin、p53及skp2蛋白在结直肠肿瘤组织中的表达及临床病理意义.方法:采用免疫组织化学法检测maspin、p53及skp2在50例结直肠腺癌,20例结直肠腺瘤、20例正常结直肠粘膜组织中的表达.结果:maspin蛋白在结直肠腺瘤和正常结直肠粘膜组织中的表达均高于结直肠腺癌(p<0.05);无淋巴结转移组maspin表达率高于淋巴结转移组(p<0.05);Dukes C,D期结直肠癌组织maspin表达率低于Dukes A、B期(p<0.05).在结直肠腺癌及腺瘤中maspin与p53的表达均呈负相关(P<0.01),然而在skp2与maspin、skp2与p53之间没有发现相关性(P>O.05).结论 :maspin的表达可能受p53基因的调控.联合检测maspin、p53及skp2在结直肠肿瘤中表达水平,对判定结直肠癌恶性程度及预后可能具有重要参考价值.
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| 关 键 词： | maspin p53 skp2 结直肠肿瘤 |
Protein expression of Maspin,P53 and Skp2 in colorectal tumors and their significance |
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| NI Jiang-tao,et al.Protein expression of Maspin,P53 and Skp2 in colorectal tumors and their significance[J].Journal of Chongqing Medical University,2010,35(1). |
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| Authors: | NI Jiang-tao |
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| Institution: | NI Jiang-tao,et al(Department of Pathology,Molecular Medicine , Tumor Research Center,Chongqing Medical University) |
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| Abstract: | Objective:Toinvestigate the role ofmaspin,p53 and Skp2 expression in the progression ofcolorectal tumors,and tounderstand their clinicopathological significance.Methods:The expression of maspin,p53 and Skp2 in colorectal adenocarcinoma(n=50),adenoma(n=20)and normal tissue(n=20)were detected by immunohistochemistry and compared with the clinicopathological tumor parameters.The relationship among the expression of maspin,p53,and Skp2 was also analyzed in colorectal tumors.Results:Maspin expression was much lo... |
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| Keywords: | maspin p53 skp2 Maspin P53 Skp2 Coloreetal tumor |
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